TY - JOUR
AU - Marrakchi H
AU - Lanéelle M
AU - Daffé M
AB - Mycolic acids are major and specific lipid components of the mycobacterial cell envelope and are essential for the survival of members of the genus Mycobacterium that contains the causative agents of both tuberculosis and leprosy. In the alarming context of the emergence of multidrug-resistant, extremely drug-resistant, and totally drug-resistant tuberculosis, understanding the biosynthesis of these critical determinants of the mycobacterial physiology is an important goal to achieve, because it may open an avenue for the development of novel antimycobacterial agents. This review focuses on the chemistry, structures, and known inhibitors of mycolic acids and describes progress in deciphering the mycolic acid biosynthetic pathway. The functional and key biological roles of these molecules are also discussed, providing a historical perspective in this dynamic area.
BT - Chemistry & biology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/24374164?dopt=Abstract
DA - 2014 Jan 16
DO - 10.1371/journal.pntd.0002845
IS - 1
J2 - Chem. Biol.
LA - eng
N2 - Mycolic acids are major and specific lipid components of the mycobacterial cell envelope and are essential for the survival of members of the genus Mycobacterium that contains the causative agents of both tuberculosis and leprosy. In the alarming context of the emergence of multidrug-resistant, extremely drug-resistant, and totally drug-resistant tuberculosis, understanding the biosynthesis of these critical determinants of the mycobacterial physiology is an important goal to achieve, because it may open an avenue for the development of novel antimycobacterial agents. This review focuses on the chemistry, structures, and known inhibitors of mycolic acids and describes progress in deciphering the mycolic acid biosynthetic pathway. The functional and key biological roles of these molecules are also discussed, providing a historical perspective in this dynamic area.
PY - 2014
SP - 67
EP - 85
T2 - Chemistry & biology
TI - Mycolic acids: structures, biosynthesis, and beyond.
VL - 21
SN - 1879-1301
ER -