TY - JOUR
KW - leprosy
KW - Review
KW - Epidemiological aspects
KW - Clinical aspects
KW - Etiopathogenic aspects
KW - Classification; Clinical diagnosis; Disease transmission
KW - infectious; Education
KW - continuing; Epidemiology; Genetic phenomena; Immunologic factors; Leprosy; Mycobacterium leprae; Signs and symptoms
AU - Lastória J
AU - Abreu MAMM
AB - Leprosy is caused by Mycobacterium leprae and has been known since biblical times. It is still endemic in many regions of the world and a public health problem in Brazil. The prevalence rate in 2011 reached 1.54 cases per 10,000 inhabitants in Brazil. The mechanism of transmission of leprosy consists of prolonged close contact between susceptible and genetically predisposed individuals and untreated multibacillary patients. Transmission occurs through inhalation of bacilli present in upper airway secretion. The nasal mucosa is the main entry or exit route of M. leprae. The deeper understanding of the structural and biological characteristics of M. leprae, the sequencing of its genome, along with the advances in understanding the mechanisms of host immune response against the bacilli, dependent on genetic susceptibility, have contributed to the understanding of the pathogenesis, variations in the clinical characteristics, and progression of the disease. This article aims to update dermatologist on epidemiological, clinical, and etiopathogenic leprosy aspects.
BT - Anais brasileiros de dermatologia
C1 - http://www.ncbi.nlm.nih.gov/pubmed/24770495?dopt=Abstract
CN - LASTORIA2014
DA - 2014 Apr
DO - 10.1590/abd1806-4841.20142450 
IS - 2
J2 - An Bras Dermatol
LA - eng
N2 - Leprosy is caused by Mycobacterium leprae and has been known since biblical times. It is still endemic in many regions of the world and a public health problem in Brazil. The prevalence rate in 2011 reached 1.54 cases per 10,000 inhabitants in Brazil. The mechanism of transmission of leprosy consists of prolonged close contact between susceptible and genetically predisposed individuals and untreated multibacillary patients. Transmission occurs through inhalation of bacilli present in upper airway secretion. The nasal mucosa is the main entry or exit route of M. leprae. The deeper understanding of the structural and biological characteristics of M. leprae, the sequencing of its genome, along with the advances in understanding the mechanisms of host immune response against the bacilli, dependent on genetic susceptibility, have contributed to the understanding of the pathogenesis, variations in the clinical characteristics, and progression of the disease. This article aims to update dermatologist on epidemiological, clinical, and etiopathogenic leprosy aspects.
PY - 2014
SP - 205
EP - 18
T2 - Anais brasileiros de dermatologia
TI - Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1.
UR - http://www.scielo.br/pdf/abd/v89n2/0365-0596-abd-89-02-0205.pdf
VL - 89
SN - 1806-4841
ER -