TY - JOUR
KW - Adolescent
KW - Adult
KW - Anemia
KW - Chemical and Drug Induced Liver Injury
KW - Child
KW - Clofazimine
KW - Dapsone
KW - Drug Therapy, Combination
KW - Female
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Methemoglobinemia
KW - Middle Aged
KW - Retrospective Studies
KW - Rifampin
AU - Kaluarachchi S I
AU - Fernandopulle B M
AU - Gunawardane B P
AB - <p>This study analyses retrospectively some of the risks associated with the use of WHO-multidrug therapy (MDT) in Sri Lanka. Case records of 3,333 new cases of leprosy attending the Central Leprosy Clinic in Colombo during 1991-1995, were analysed for adverse drug reactions involving the liver and blood. There were 81 reports of suspected hepatic or haematological adverse reactions associated with the use of MDT, of which 39 were classified as haemolytic anaemia, 25 as toxic hepatitis, 2 as methaemoglobinaemia and 15 as anaemia. Dapsone, was incriminated in the majority of adverse reactions (72%). Adverse drug reactions were more common in female than male subjects (55% vs 45%; P < 0.5), but there was no significant differences between the age groups. Majority of adverse reactions was seen within the first three months of initiation of MDT. This study in no way undermines the benefits of MDT but highlights the risks and suggests measures to minimize these risks.</p>
BT - Indian journal of leprosy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/11579648?dopt=Abstract
CN - Infolep Library - available
DA - 2001 Apr-Jun
IS - 2
J2 - Indian J Lepr
LA - eng
N2 - <p>This study analyses retrospectively some of the risks associated with the use of WHO-multidrug therapy (MDT) in Sri Lanka. Case records of 3,333 new cases of leprosy attending the Central Leprosy Clinic in Colombo during 1991-1995, were analysed for adverse drug reactions involving the liver and blood. There were 81 reports of suspected hepatic or haematological adverse reactions associated with the use of MDT, of which 39 were classified as haemolytic anaemia, 25 as toxic hepatitis, 2 as methaemoglobinaemia and 15 as anaemia. Dapsone, was incriminated in the majority of adverse reactions (72%). Adverse drug reactions were more common in female than male subjects (55% vs 45%; P < 0.5), but there was no significant differences between the age groups. Majority of adverse reactions was seen within the first three months of initiation of MDT. This study in no way undermines the benefits of MDT but highlights the risks and suggests measures to minimize these risks.</p>
PY - 2001
SP - 121
EP - 9
T2 - Indian journal of leprosy
TI - Hepatic and haematological adverse reactions associated with the use of multidrug therapy in leprosy--a five year retrospective study.
VL - 73
SN - 0254-9395
ER -