Multidrug therapy (MDT) for leprosy was recommended by WHO with a triple drug regimen of Dapsone, Rifampicin and Clofazimine, which is still the best treatment for leprosy. Side effects of these are commonly seen in clinical practice. Herein we present to you a case of 63 year old male patient who presented to the OPD with gastro-intestinal symptoms, paresthesias and difficulty in walking. It was only by proper history taking (he has been continuing MDT for the past 43 years), the diagnosis could be made. Further workup revealed presence of methemoglobinemia, atrophic gastritis, peripheral neuropathy and subacute combined degeneration of spinal cord. Prompt treatment and withdrawal of the drug lead to improvement of the symptoms.
BT - Journal of Evidence Based Medicine and Health Care CN - VENGADAKRISHNAN2015 IS - 2 J2 - J of Evidence Based Med & Hlthcare LA - eng N2 -Multidrug therapy (MDT) for leprosy was recommended by WHO with a triple drug regimen of Dapsone, Rifampicin and Clofazimine, which is still the best treatment for leprosy. Side effects of these are commonly seen in clinical practice. Herein we present to you a case of 63 year old male patient who presented to the OPD with gastro-intestinal symptoms, paresthesias and difficulty in walking. It was only by proper history taking (he has been continuing MDT for the past 43 years), the diagnosis could be made. Further workup revealed presence of methemoglobinemia, atrophic gastritis, peripheral neuropathy and subacute combined degeneration of spinal cord. Prompt treatment and withdrawal of the drug lead to improvement of the symptoms.
PY - 2015 SP - 200 EP - 205 T2 - Journal of Evidence Based Medicine and Health Care TI - Prolonged use of multidrug therapy for leprosy leading to multiple complications UR - http://www.jebmh.com/data_pdf/1_Vengadakrishnan.pdf VL - 2 ER -