TY - JOUR
KW - leprosy
KW - Cellulair dammage
KW - Brazil
KW - Antioxidants
AU - Schalcher TR
AU - Vieira JLF
AU - Salgado CG
AU - Borges RDS
AU - Monteiro MC
AB - Introduction The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy. Methods We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients. Results We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased. Conclusions The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients.
BT - Revista da Sociedade Brasileira de Medicina Tropical
C1 - http://www.ncbi.nlm.nih.gov/pubmed/24270257?dopt=Abstract
DA - 2013 Sept-Oct
DO - 10.1590/0037-8682-1506-2013
IS - 5
J2 - Rev. Soc. Bras. Med. Trop.
LA - eng
N2 - Introduction The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy. Methods We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients. Results We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased. Conclusions The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients.
PY - 2013
SP - 645
EP - 649
T2 - Revista da Sociedade Brasileira de Medicina Tropical
TI - Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients.
VL - 46
SN - 1678-9849
ER -