TY - JOUR
KW - Adult
KW - Antibiotics, Antitubercular
KW - Antitubercular Agents
KW - Child
KW - Disease Management
KW - Extensively Drug-Resistant Tuberculosis
KW - Female
KW - HIV Infections
KW - Humans
KW - Incidence
KW - Male
KW - Population Surveillance
KW - Retrospective Studies
KW - Rifampin
KW - Sex Factors
KW - Tuberculosis, Multidrug-Resistant
KW - Zambia
AU - Kapata N
AU - Chanda-Kapata P
AU - Bates M
AU - Mwaba P
AU - Cobelens F
AU - Grobusch M
AU - Zumla A
AB - <p><b>BACKGROUND: </b>Multidrug-resistant tuberculosis (MDR-TB) is posing a great threat to global TB control. The burden in Zambia is not well defined because routine surveillance data are scarce. We reviewed national MDR-TB data for the last decade to inform future public health policy with respect to MDR-TB in Zambia.</p><p><b>METHOD: </b>Retrospective review of national surveillance of MDR-TB data, TB programme and laboratory reports between 2000 and 2011.</p><p><b>RESULTS: </b>The total number of DSTs performed during this 11-year period was 2,038 and accounted for 2.6% (2,038/78,639) of all the retreatment cases notified. The total number of diagnosed MDR-TB cases for this period was 446, of which 56.3% (251/446) were male and 41.7% (186/446) female. Only one child was found to have MDR-TB. Poly-drug resistance accounted for 18.9% (172/911) of the DR-TB cases and 8.4% of the total DSTs. 8.8% (80/911) of the DR-TB cases showed either rifampicin mono- or poly-resistance other than MDR-TB. No XDR-TB was reported. There were no data available on DR-TB and HIV co-infection. Only 65 MDR-TB patients were notified and put on second-line treatment according to WHO guidelines.</p><p><b>CONCLUSIONS: </b>Multidrug-resistant tuberculosis may be an emerging challenge in Zambia. There is a need to invest in improving the capacity of the TB programme to detect and manage MDR-TB.</p>
BT - Tropical medicine & international health : TM & IH
C1 - http://www.ncbi.nlm.nih.gov/pubmed/24033538?dopt=Abstract
DA - 2013 Nov
DO - 10.1111/tmi.12183
IS - 11
J2 - Trop. Med. Int. Health
LA - eng
N2 - <p><b>BACKGROUND: </b>Multidrug-resistant tuberculosis (MDR-TB) is posing a great threat to global TB control. The burden in Zambia is not well defined because routine surveillance data are scarce. We reviewed national MDR-TB data for the last decade to inform future public health policy with respect to MDR-TB in Zambia.</p><p><b>METHOD: </b>Retrospective review of national surveillance of MDR-TB data, TB programme and laboratory reports between 2000 and 2011.</p><p><b>RESULTS: </b>The total number of DSTs performed during this 11-year period was 2,038 and accounted for 2.6% (2,038/78,639) of all the retreatment cases notified. The total number of diagnosed MDR-TB cases for this period was 446, of which 56.3% (251/446) were male and 41.7% (186/446) female. Only one child was found to have MDR-TB. Poly-drug resistance accounted for 18.9% (172/911) of the DR-TB cases and 8.4% of the total DSTs. 8.8% (80/911) of the DR-TB cases showed either rifampicin mono- or poly-resistance other than MDR-TB. No XDR-TB was reported. There were no data available on DR-TB and HIV co-infection. Only 65 MDR-TB patients were notified and put on second-line treatment according to WHO guidelines.</p><p><b>CONCLUSIONS: </b>Multidrug-resistant tuberculosis may be an emerging challenge in Zambia. There is a need to invest in improving the capacity of the TB programme to detect and manage MDR-TB.</p>
PY - 2013
SP - 1386
EP - 91
T2 - Tropical medicine & international health : TM & IH
TI - Multidrug-resistant TB in Zambia: review of national data from 2000 to 2011.
VL - 18
SN - 1365-3156
ER -