TY - JOUR
KW - Genome, Bacterial
KW - History, 15th Century
KW - History, 16th Century
KW - History, 17th Century
KW - History, 18th Century
KW - History, 19th Century
KW - History, Ancient
KW - History, Medieval
KW - Humans
KW - leprosy
KW - Metagenomics
KW - Mycobacterium leprae
KW - Mycobacterium tuberculosis
KW - Tuberculosis
AU - Donoghue H
AB - <p>Leprosy and tuberculosis were widespread in the past and remain significant diseases today. Comparison of ancient and modern genomes of Mycobacterium leprae and Mycobacterium tuberculosis gives insight into their evolution and a calibration of the timescale for observed changes. Recently, whole genome sequencing has revealed genotypes and mixed-strain infections.</p>
BT - Trends in microbiology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/23932433?dopt=Abstract
DA - 2013 Sep
DO - 10.1016/j.tim.2013.07.007
IS - 9
J2 - Trends Microbiol.
LA - eng
N2 - <p>Leprosy and tuberculosis were widespread in the past and remain significant diseases today. Comparison of ancient and modern genomes of Mycobacterium leprae and Mycobacterium tuberculosis gives insight into their evolution and a calibration of the timescale for observed changes. Recently, whole genome sequencing has revealed genotypes and mixed-strain infections.</p>
PY - 2013
SP - 448
EP - 50
T2 - Trends in microbiology
TI - Insights into ancient leprosy and tuberculosis using metagenomics.
VL - 21
SN - 1878-4380
ER -