TY - JOUR KW - Systematic review KW - Neuropathy KW - leprosy KW - diagnosis AU - Garbino JA AU - Marques Jr W AU - Barreto J AU - Heise CO AU - Rodrigues MMJ AU - Antunes S AU - Soares CT AU - Floriano MC AU - Nery JA AU - Bianconcini Trindade MA AU - Carvalho NB AU - Andrada NC AU - Barreira AA AU - Cunha Lopes Virmond M AB -

The authors proposed a systematic review on the current concepts of primary neural leprosy by consulting the following online databases: MEDLINE, Lilacs/SciELO, and Embase. Selected studies were classified based on the degree of recommendation and levels of scientific evidence according to the “Oxford Centre for Evidence-based Medicine”. The following aspects were reviewed: cutaneous clinical and laboratorial investigations, i.e. skin clinical exam, smears, and biopsy, and Mitsuda's reaction; neurological investigation (anamnesis, electromyography and nerve biopsy); serological investigation and molecular testing, i.e. serological testing for the detection of the phenolic glycolipid 1 (PGL-I) and the polymerase chain reaction (PCR); and treatment (classification criteria for the definition of specific treatment, steroid treatment, and cure criteria).

BT - Arquivos de Neuro-Psiquiatria C1 -

http://www.ncbi.nlm.nih.gov/pubmed/23828524

CN - GARBINO 2013 DO - 10.1590/0004-282X20130046 IS - 6 J2 - Arq. Neuro-Psiquiatr LA - eng N2 -

The authors proposed a systematic review on the current concepts of primary neural leprosy by consulting the following online databases: MEDLINE, Lilacs/SciELO, and Embase. Selected studies were classified based on the degree of recommendation and levels of scientific evidence according to the “Oxford Centre for Evidence-based Medicine”. The following aspects were reviewed: cutaneous clinical and laboratorial investigations, i.e. skin clinical exam, smears, and biopsy, and Mitsuda's reaction; neurological investigation (anamnesis, electromyography and nerve biopsy); serological investigation and molecular testing, i.e. serological testing for the detection of the phenolic glycolipid 1 (PGL-I) and the polymerase chain reaction (PCR); and treatment (classification criteria for the definition of specific treatment, steroid treatment, and cure criteria).

PY - 2013 T2 - Arquivos de Neuro-Psiquiatria TI - Primary neural leprosy : systematic review TT - Hanseníase neural primária: revisão sistemática UR - http://www.scielo.br/pdf/anp/v71n6/0004-282X-anp-71-06-397.pdf VL - 71 ER -