TY - JOUR
KW - Type 1 reaction
KW - leprosy
KW - Intra-granuloma edema
KW - Hypersensitivity reaction
KW - Dermatopathology
KW - Borderline leprosy
AU - Thomas M
AU - Ponnaiya J
AU - Emmanuel M
AU - Richard J
AB - Even though type 1 lepra reaction (TIR) is a commonly encountered clinical problem, its histology has not yet
been clearly delineated. This study attempts to enumerate the most sensitive parameters for the histological
diagnosis of TIR. Case records between March 2007 and September 2007 of patients with TIR were reviewed
and the biopsies were evaluated by a pathologist blinded to the previous diagnoses. Twenty three patients
were included in the study. The most sensitive parameters in our study were dermal edema, intra-granuloma
edema and giant cell size. Though clinical findings should remain the mainstay of diagnosis of TIR, the above
mentioned parameters should be evaluated in biopsies of leprosy to look for signs of reaction which might
otherwise be missed.
BT - Indian journal of leprosy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/24046908
CN - THOMAS 2013
IS - 1
J2 - Indian J Lepr
LA - eng
N2 - Even though type 1 lepra reaction (TIR) is a commonly encountered clinical problem, its histology has not yet
been clearly delineated. This study attempts to enumerate the most sensitive parameters for the histological
diagnosis of TIR. Case records between March 2007 and September 2007 of patients with TIR were reviewed
and the biopsies were evaluated by a pathologist blinded to the previous diagnoses. Twenty three patients
were included in the study. The most sensitive parameters in our study were dermal edema, intra-granuloma
edema and giant cell size. Though clinical findings should remain the mainstay of diagnosis of TIR, the above
mentioned parameters should be evaluated in biopsies of leprosy to look for signs of reaction which might
otherwise be missed.
PY - 2013
SP - 1
EP - 4
T2 - Indian journal of leprosy
TI - Type I reaction in leprosy : A histopathological analysis
UR - http://www.ijl.org.in/oct-dec/1%20Thomas%20(1-4)%20f.pdf
VL - 85
ER -