TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Case-Control Studies
KW - Child
KW - Female
KW - Humans
KW - leprosy
KW - Male
KW - Mast Cells
KW - Middle Aged
KW - Skin Diseases, Bacterial
AU - Mysorekar V V
AU - Dandekar C P
AU - Rao S G
AB - <p>The density and distribution of mast cells was assessed in skin biopsies of 118 untreated leprosy cases and 20 healthy individuals taken as controls. Mast cells were present in only small numbers in the skin biopsies of healthy individuals. Significantly higher mast cell counts were obtained in the skin lesions of indeterminate leprosy (P < 0.01). The mast cell count in the tuberculoid group was significantly lower than that in the lepromatous group (P < 0.05). The lepromatous group also showed increased mast cell degranulation and altered morphology. The mast cell distribution in the skin biopsies of the two groups was, however, similar. The mast cell count in leprosy is probably determined by the pattern of cytokines released by the T lymphocytes. However, the influence of mast cells on the outcome of the disease needs to be evaluated further.</p>
BT - Leprosy review
C1 - http://www.ncbi.nlm.nih.gov/pubmed/11355515?dopt=Abstract
CN - Infolep Library - available
DA - 2001 Mar
DO - 10.5935/0305-7518.20010006
IS - 1
J2 - Lepr Rev
LA - eng
N2 - <p>The density and distribution of mast cells was assessed in skin biopsies of 118 untreated leprosy cases and 20 healthy individuals taken as controls. Mast cells were present in only small numbers in the skin biopsies of healthy individuals. Significantly higher mast cell counts were obtained in the skin lesions of indeterminate leprosy (P < 0.01). The mast cell count in the tuberculoid group was significantly lower than that in the lepromatous group (P < 0.05). The lepromatous group also showed increased mast cell degranulation and altered morphology. The mast cell distribution in the skin biopsies of the two groups was, however, similar. The mast cell count in leprosy is probably determined by the pattern of cytokines released by the T lymphocytes. However, the influence of mast cells on the outcome of the disease needs to be evaluated further.</p>
PY - 2001
SP - 29
EP - 34
T2 - Leprosy review
TI - Mast cells in leprosy skin lesions.
UR - http://leprev.ilsl.br/pdfs/2001/v72n1/pdf/v72n1a06.pdf
VL - 72
SN - 0305-7518
ER -