TY - JOUR
KW - leprosy
KW - Hypersensitivity
KW - Hepatitis
KW - Eosinophilia
KW - Drug rash
KW - Dapsone
AU - Vinod KV
AU - Arun K
AU - Dutta TK
AB - Dapsone can cause several adverse effects, the most serious being dapsone hypersensitivity syndrome (DHS), which is potentially fatal. Here we report a case of severe, life threatening dapsone systemic hypersensitivity syndrome in a 17-year-old male who presented with high grade fever, eosinophilia, lymphadenopathy, skin rash, hepatitis and encephalopathy, which was managed successfully with oral steroids. The case is being reported to emphasize the need for timely diagnosis and prompt treatment of this rare complication for successful outcomes. DHS is also reviewed in brief.
BT - Journal of Pharmacology & Pharmacotherapeutics
CN - VINOD2013
DO - 10.4103/0976-500X.110917
IS - 2
J2 - J Pharmacol Pharmacothe
LA - eng
N2 - Dapsone can cause several adverse effects, the most serious being dapsone hypersensitivity syndrome (DHS), which is potentially fatal. Here we report a case of severe, life threatening dapsone systemic hypersensitivity syndrome in a 17-year-old male who presented with high grade fever, eosinophilia, lymphadenopathy, skin rash, hepatitis and encephalopathy, which was managed successfully with oral steroids. The case is being reported to emphasize the need for timely diagnosis and prompt treatment of this rare complication for successful outcomes. DHS is also reviewed in brief.
PY - 2013
SP - 158
EP - 160
T2 - Journal of Pharmacology & Pharmacotherapeutics
TI - Dapsone hypersensitivity syndrome: A rare life threatening complication of dapsone therapy
UR - http://www.lepra.org.uk/platforms/lepra/files/lr/Dec12/Lep370-377.pdf
VL - 4
ER -