Aim The objective of this study was to evaluate the influence of HLA and MICA alleles in the development of leprosy and its clinical forms in a population with leprosy from the region of Santo Antônio do Prata – PA, Brazil. Methods Fifty-one families were genotyped for HLA and MICA genes by PCR-SSOP, LuminexÒ methodology (One Lambda) and Dynal AutoRELITM 48 Instrument (Invitrogen) Dynal-RELITMSSO HLA Typing. Statistical Analysis was based on the Transmission Disequilibrium Test (TDT) software FBAT 2.0.4. Results The alleles HLA-A∗03/11 (P=0.041), HLA-C∗04 (P=0.025), HLA-DRB1∗16 (P=0.048), DQB1∗05 (P=0.004) and MICA∗002 (P = 0.003) showed significant positive association with the occurrence of leprosy in this population, while the alleles HLA-C∗12 (P = 0.095), DRB1∗15/16 (P = 0.055), and MICA∗008 (P = 0.075) showed a tendency to positive association. Conclusions This study suggests that the alleles HLA-A∗03/∗11, HLA-C∗04, HLA-DRB1∗16, DQB1∗05 and MICA∗002 may be associated with susceptibility to leprosy in this population and HLA-C∗12, DRB1∗15/16 and MICA∗008 should be further investigated.
BT - Human Immunology DA - 10/2012 DO - 10.1016/j.humimm.2012.07.294 J2 - Hum Vaccin LA - eng N1 -ASHI 2012 Puerto Rico Abstracts Issue
N2 -Aim The objective of this study was to evaluate the influence of HLA and MICA alleles in the development of leprosy and its clinical forms in a population with leprosy from the region of Santo Antônio do Prata – PA, Brazil. Methods Fifty-one families were genotyped for HLA and MICA genes by PCR-SSOP, LuminexÒ methodology (One Lambda) and Dynal AutoRELITM 48 Instrument (Invitrogen) Dynal-RELITMSSO HLA Typing. Statistical Analysis was based on the Transmission Disequilibrium Test (TDT) software FBAT 2.0.4. Results The alleles HLA-A∗03/11 (P=0.041), HLA-C∗04 (P=0.025), HLA-DRB1∗16 (P=0.048), DQB1∗05 (P=0.004) and MICA∗002 (P = 0.003) showed significant positive association with the occurrence of leprosy in this population, while the alleles HLA-C∗12 (P = 0.095), DRB1∗15/16 (P = 0.055), and MICA∗008 (P = 0.075) showed a tendency to positive association. Conclusions This study suggests that the alleles HLA-A∗03/∗11, HLA-C∗04, HLA-DRB1∗16, DQB1∗05 and MICA∗002 may be associated with susceptibility to leprosy in this population and HLA-C∗12, DRB1∗15/16 and MICA∗008 should be further investigated.
PY - 2012 EP - 153 T2 - Human Immunology TI - 168-P: ASSOCIATION OF HLA AND MICA ALLELES WITH LEPROSY IN FAMILIES FROM AN ENDEMIC AREA OF THE NORTH OF BRAZIL UR - http://www.sciencedirect.com/science/article/pii/S0198885912004594 VL - 73, Supplement SN - 0198-8859 ER -