By 1926, two French physicians working in Indochina, R. Pons and L. Chastel, have suggested to treat leprosy by subcutaneous injections of bacillus Calmette-Guerin. This treatment appeared efficient since the lepromatous lesions quickly regressed and the Hansen bacillus disappeared from the nasal mucus. These results were quickly confirmed by other authors. They were all more appreciated than, at this time, the Chaulmoogra oil and its products, the only available drugs, were poorly efficient against the disease. Nevertheless, although not a panacea, the BCG therapy allowed to relieve these unfortunate patients until the beginning of the 1950's when an effective treatment by sulfones was at length available.
BT - Bulletin de la Societe de pathologie exotique (1990) C1 - http://www.ncbi.nlm.nih.gov/pubmed/23456485?dopt=Abstract CN - CHASTEL 2013 DA - 2013 May DO - 10.1007/s13149-013-0280-2 IS - 2 J2 - Bull Soc Pathol Exot LA - fre N2 -By 1926, two French physicians working in Indochina, R. Pons and L. Chastel, have suggested to treat leprosy by subcutaneous injections of bacillus Calmette-Guerin. This treatment appeared efficient since the lepromatous lesions quickly regressed and the Hansen bacillus disappeared from the nasal mucus. These results were quickly confirmed by other authors. They were all more appreciated than, at this time, the Chaulmoogra oil and its products, the only available drugs, were poorly efficient against the disease. Nevertheless, although not a panacea, the BCG therapy allowed to relieve these unfortunate patients until the beginning of the 1950's when an effective treatment by sulfones was at length available.
PY - 2013 SP - 126 EP - 30 T2 - Bulletin de la Societe de pathologie exotique (1990) TI - [About a note published in 1926 on a BCG vaccine trial in leprosy treatment]. TT - À propos d’une note de 1926 sur un essai du BCG dans le traitement de la lèpre UR - https://bspe.revuesonline.com/gratuit/BSPE106_2_13149_2013_Article_280.pdf VL - 106 SN - 1961-9049 ER -