TY - JOUR
KW - Africa South of the Sahara
KW - Buruli ulcer
KW - China
KW - Communicable Diseases, Emerging
KW - Humans
KW - Japan
KW - Macrolides
KW - Mycobacterium ulcerans
KW - Plasmids
KW - Polyketide Synthases
KW - Virulence Factors
AU - Nakanaga K
AU - Yotsu RR
AU - Hoshino Y
AU - Suzuki K
AU - Makino M
AU - Ishii N
AB - <p>Buruli ulcer (BU) is an emerging human disease caused by Mycobacterium ulcerans, which mainly affects the extremities. It is most endemic in sub-Saharan Africa; however, it has been reported worldwide, including in some non-tropical areas. "M. ulcerans subsp. shinshuense" is proposed as a subspecies of M. ulcerans, which have been reported from Japan and China. A total of 35 BU cases have been reported as of November 2012. Although M. ulcerans is categorized as nontuberculous mycobacteria, it has some unique characteristics that could only be observed in this bacterium. It possesses a giant virulent plasmid, composed of 174-kbp nucleotides, coding polyketide synthase to produce macrolide toxin called mycolactone. The discovery of such a linkage of plasmid and its pathogenesis has not been reported in other human disease-causing mycobacteria.</p>
BT - Japanese journal of infectious diseases
C1 - http://www.ncbi.nlm.nih.gov/pubmed/23514902?dopt=Abstract
CN - NAKANAGA2013
DA - 2013
IS - 2
J2 - Jpn. J. Infect. Dis.
LA - eng
N2 - <p>Buruli ulcer (BU) is an emerging human disease caused by Mycobacterium ulcerans, which mainly affects the extremities. It is most endemic in sub-Saharan Africa; however, it has been reported worldwide, including in some non-tropical areas. "M. ulcerans subsp. shinshuense" is proposed as a subspecies of M. ulcerans, which have been reported from Japan and China. A total of 35 BU cases have been reported as of November 2012. Although M. ulcerans is categorized as nontuberculous mycobacteria, it has some unique characteristics that could only be observed in this bacterium. It possesses a giant virulent plasmid, composed of 174-kbp nucleotides, coding polyketide synthase to produce macrolide toxin called mycolactone. The discovery of such a linkage of plasmid and its pathogenesis has not been reported in other human disease-causing mycobacteria.</p>
PY - 2013
SP - 83
EP - 8
T2 - Japanese journal of infectious diseases
TI - Buruli ulcer and mycolactone-producing mycobacteria.
UR - https://www.jstage.jst.go.jp/article/yoken/66/2/66_83/_pdf
VL - 66
SN - 1884-2836
ER -