TY - JOUR
KW - Netherton's syndrome
KW - leprosy
KW - lepromatous leprosy
AU - Oliveira F L
AU - Vasconcellos B O
AU - Morais T S
AU - Nascimento M B
AU - Teles R
AU - Costa Nery J A
AU - Miranda M J S
AU - Azulay-Abulafia L
AB - Objectives  Netherton's syndrome (NS) is a rare autosomal recessive condition, first described in 1958, which involves a complex immunological dysfunction, ichthyosiform dermatitis, and erythroderma, characteristic defects of the hair shaft and atopy. Recurrent bacterial infection in the skin of patients with NS is frequent. Methods  This paper represents the first case report of leprosy and concurrent NS. Discussion  This case merits discussion among doctors in endemic and non-endemic areas to evaluate the chronic use of systemic corticosteroids as a risk factor for leprosy. The present patient came from an endemic area of leprosy and was treated chronically with systemic corticosteroids for erythroderma. This treatment, along with the immunodeficiency related to the syndrome and caused by a genetic mutation in SPINK5, may be a facilitating factor for the infection.
BT - International journal of dermatology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/23347305?dopt=Abstract
DA - 02/2013 
DO - 10.1111/j.1365-4632.2012.05620.x
IS - 2
J2 - Int. J. Dermatol.
LA - eng
N2 - Objectives  Netherton's syndrome (NS) is a rare autosomal recessive condition, first described in 1958, which involves a complex immunological dysfunction, ichthyosiform dermatitis, and erythroderma, characteristic defects of the hair shaft and atopy. Recurrent bacterial infection in the skin of patients with NS is frequent. Methods  This paper represents the first case report of leprosy and concurrent NS. Discussion  This case merits discussion among doctors in endemic and non-endemic areas to evaluate the chronic use of systemic corticosteroids as a risk factor for leprosy. The present patient came from an endemic area of leprosy and was treated chronically with systemic corticosteroids for erythroderma. This treatment, along with the immunodeficiency related to the syndrome and caused by a genetic mutation in SPINK5, may be a facilitating factor for the infection.
PY - 2013
SP - 186
EP - 90
T2 - International journal of dermatology
TI - Netherton's syndrome and lepromatous leprosy: a mere coincidence?
VL - 52
SN - 1365-4632
ER -