TY - JOUR
KW - Young Adult
KW - Tumor Necrosis Factor-alpha
KW - Promoter Regions, Genetic
KW - Population Groups
KW - Polymorphism, Restriction Fragment Length
KW - Polymorphism, Genetic
KW - polymerase chain reaction
KW - Middle Aged
KW - Mexico
KW - Male
KW - Leprosy, lepromatous
KW - Interleukin-10
KW - Humans
KW - Genetic Testing
KW - Genetic Predisposition to Disease
KW - Gene Frequency
KW - Full text online
KW - Female
KW - Case-Control Studies
KW - Alleles
KW - Adult
AU - Velarde Félix J S
AU - Cázarez-Salazar S
AU - RÍOS-TOSTADO J J
AU - FLORES-GARCIA A
AU - Rangel-Villalobos H
AU - MURILLO-LLANES J
AB - Several human genetic variants have been associated with susceptibility or resistance to leprosy. The aim of this study was to assess whether gene polymorphisms of -308 G/A TNF-alpha and -819 T/C IL-10 are associated with lepromatous leprosy in Mexican mestizos patients from northwest Mexico. We genotyped these polymorphisms by means of polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLPs) in 68 patients with lepromatous leprosy and 144 healthy Mexican Mestizos controls. We found that the -308G TNF-alpha allele was predominant in both cases (94.3%) and controls (92.3%) without statistical significance and the frequencies of -819C IL-10 allele were also similar for the cases (56.0%) and controls (59.0%). These negative findings suggest that other genes or polymorphisms may be important in the susceptibility to leprosy infection in the Mexican mestizos.
BT - Leprosy review
C1 - http://www.ncbi.nlm.nih.gov/pubmed/22655468?dopt=Abstract
CN - FELIX2012
DA - 03/2012
IS - 1
J2 - Lepr Rev
LA - eng
N2 - Several human genetic variants have been associated with susceptibility or resistance to leprosy. The aim of this study was to assess whether gene polymorphisms of -308 G/A TNF-alpha and -819 T/C IL-10 are associated with lepromatous leprosy in Mexican mestizos patients from northwest Mexico. We genotyped these polymorphisms by means of polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLPs) in 68 patients with lepromatous leprosy and 144 healthy Mexican Mestizos controls. We found that the -308G TNF-alpha allele was predominant in both cases (94.3%) and controls (92.3%) without statistical significance and the frequencies of -819C IL-10 allele were also similar for the cases (56.0%) and controls (59.0%). These negative findings suggest that other genes or polymorphisms may be important in the susceptibility to leprosy infection in the Mexican mestizos.
PY - 2012
SP - 34
EP - 9
T2 - Leprosy review
TI - Lack of effects of the TNF-alpha and IL-10 gene polymorphisms in Mexican patients with lepromatous leprosy.
VL - 83
SN - 0305-7518
ER -