TY - JOUR
KW - leprosy
KW - Immune response
KW - Human monocytes.
KW - Galectin-3
AU - Chung A
AU - Sieling PA
AU - Schenk M
AU - Teles R
AU - Krutzik SR
AU - Hsu D
AU - Liu F
AU - Sarno E
AU - Stenger S
AU - Modlin RL
AU - Lee DJ
AB - Galectin-3 is a β-galactoside binding lectin widely expressed on epithelial and hematopoietic cells and its expression is frequently associated with a poor prognosis in cancer. Since it has not been well-studied in human infectious disease, we examined galectin-3 expression in mycobacterial infection by studying leprosy, an intracellular infection caused by Mycobacterium leprae. Galectin-3 was highly expressed on macrophages in lesions of patients with the clinically progressive lepromatous form of leprosy; in contrast, galectin-3 was almost undetectable in self-limited tuberculoid lesions. We investigated the potential function of galectin-3 in cell-mediated immunity using peripheral blood monocytes. Galectin-3 enhanced monocyte IL-10 production to a TLR2/1 ligand, while IL-12p40 secretion was unaffected. Furthermore, galectin-3 diminished monocyte to DC differentiation and T cell antigen presentation. These data demonstrate an association of galectin-3 with unfavorable host response in leprosy and a potential mechanism for impaired host defense in humans.
BT - The Journal of infectious diseases
C1 - http://www.ncbi.nlm.nih.gov/pubmed/23255567?dopt=Abstract
DA - 2012 Dec 18
J2 - J. Infect. Dis.
LA - eng
N2 - Galectin-3 is a β-galactoside binding lectin widely expressed on epithelial and hematopoietic cells and its expression is frequently associated with a poor prognosis in cancer. Since it has not been well-studied in human infectious disease, we examined galectin-3 expression in mycobacterial infection by studying leprosy, an intracellular infection caused by Mycobacterium leprae. Galectin-3 was highly expressed on macrophages in lesions of patients with the clinically progressive lepromatous form of leprosy; in contrast, galectin-3 was almost undetectable in self-limited tuberculoid lesions. We investigated the potential function of galectin-3 in cell-mediated immunity using peripheral blood monocytes. Galectin-3 enhanced monocyte IL-10 production to a TLR2/1 ligand, while IL-12p40 secretion was unaffected. Furthermore, galectin-3 diminished monocyte to DC differentiation and T cell antigen presentation. These data demonstrate an association of galectin-3 with unfavorable host response in leprosy and a potential mechanism for impaired host defense in humans.
PY - 2012
T2 - The Journal of infectious diseases
TI - Galectin-3 regulates the innate immune response of human monocytes.
SN - 1537-6613
ER -