TY - JOUR
KW - Autoantibodies
KW - Case-Control Studies
KW - Ceramides
KW - Enzyme-Linked Immunosorbent Assay
KW - HIV Infections
KW - Humans
KW - Immunohistochemistry
KW - leprosy
KW - Myelin P0 Protein
KW - Peripheral Nervous System Diseases
AU - Raju R
AU - Devi K
AU - Mehervani C
AU - Kumar SA
AU - Meena A K
AU - Reddy P P
AU - Pranay P
AU - Jain S
AU - Archelos-Gracia J J
AU - Suneetha S
AU - Suneetha LM
AB - <p>Anti neural antibodies are known to play a role in the immunopathogenesis of nerve damage in leprosy and HIV/AIDS. Myelin Protein zero (P0) and ceramide are two nerve components which maintain the integrity of the peripheral nerve. The present study was undertaken to identify antibodies to myelin P0 and ceramide in the sera of treated leprosy patients, HIV positive individuals and healthy subjects using enzyme linked immunosorbant assay (ELISA). The results revealed that treated leprosy patients continue to have significantly elevated myelin P0 and ceramide antibody levels as compared to healthy subjects (P < 0.05). The elevated antibody response to myelin P0 and ceramide in leprosy patients indicate a low grade autoimmune activity that perpetuates nerve damage in treated leprosy. There was no significant difference in the myelin P0 and ceramide antibody levels between HIV positive and healthy subjects (P > 0.05) suggesting that these antibodies do not play a role in early HIV infection.</p>
BT - Neurochemical research
C1 - http://www.ncbi.nlm.nih.gov/pubmed/21234675?dopt=Abstract
DA - 2011 May
DO - 10.1007/s11064-010-0397-7
IS - 5
J2 - Neurochem. Res.
LA - eng
N2 - <p>Anti neural antibodies are known to play a role in the immunopathogenesis of nerve damage in leprosy and HIV/AIDS. Myelin Protein zero (P0) and ceramide are two nerve components which maintain the integrity of the peripheral nerve. The present study was undertaken to identify antibodies to myelin P0 and ceramide in the sera of treated leprosy patients, HIV positive individuals and healthy subjects using enzyme linked immunosorbant assay (ELISA). The results revealed that treated leprosy patients continue to have significantly elevated myelin P0 and ceramide antibody levels as compared to healthy subjects (P < 0.05). The elevated antibody response to myelin P0 and ceramide in leprosy patients indicate a low grade autoimmune activity that perpetuates nerve damage in treated leprosy. There was no significant difference in the myelin P0 and ceramide antibody levels between HIV positive and healthy subjects (P > 0.05) suggesting that these antibodies do not play a role in early HIV infection.</p>
PY - 2011
SP - 766
EP - 73
T2 - Neurochemical research
TI - Antibodies to myelin P0 and ceramide perpetuate neuropathy in long standing treated leprosy patients.
VL - 36
SN - 1573-6903
ER -