TY - JOUR
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Case-Control Studies
KW - Female
KW - Genetic Predisposition to Disease
KW - Humans
KW - Inflammatory Bowel Diseases
KW - Interferon-gamma
KW - Interleukin-12 Subunit p40
KW - Interleukin-18 Receptor alpha Subunit
KW - leprosy
KW - Male
KW - Middle Aged
KW - Polymorphism, Single Nucleotide
AU - Liu H
AU - Irwanto A
AU - Tian H
AU - Fu X
AU - Yu Y
AU - Yu G
AU - Low H
AU - Chu T
AU - Li Y
AU - Shi B
AU - Chen M
AU - Sun Y
AU - Yuan C
AU - Lu N
AU - You J
AU - Bao F
AU - Li J
AU - Liu J
AU - Liu H
AU - Liu D
AU - Yu X
AU - Zhang L
AU - Yang Q
AU - Wang N
AU - Niu G
AU - Ma S
AU - Zhou Y
AU - Wang C
AU - Chen S
AU - Zhang X
AU - Liu J
AU - Zhang F
AB - <p>Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10(-19); odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10(-18); OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy. Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-γ production in leprosy, and together with previous findings, it demonstrates the shared genetic susceptibility between infectious and inflammatory diseases.</p>
BT - American journal of human genetics
C1 - http://www.ncbi.nlm.nih.gov/pubmed/23103228?dopt=Abstract
CN - LIU 2012
DA - 2012 Nov 02
DO - 10.1016/j.ajhg.2012.09.010
IS - 5
J2 - Am. J. Hum. Genet.
LA - eng
N2 - <p>Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10(-19); odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10(-18); OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy. Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-γ production in leprosy, and together with previous findings, it demonstrates the shared genetic susceptibility between infectious and inflammatory diseases.</p>
PY - 2012
SP - 935
EP - 41
T2 - American journal of human genetics
TI - Identification of IL18RAP/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases.
UR - http://download.cell.com/AJHG/pdf/PIIS0002929712005137.pdf?intermediate=true
VL - 91
SN - 1537-6605
ER -