TY - JOUR
KW - Asian Continental Ancestry Group
KW - Crohn Disease
KW - Family
KW - Gene Expression Regulation
KW - Genetic Predisposition to Disease
KW - genotype
KW - Humans
KW - leprosy
KW - Nod2 Signaling Adaptor Protein
KW - Polymorphism, Single Nucleotide
KW - Signal Transduction
KW - Vietnam
AU - Grant A
AU - Alter A
AU - Huong NT
AU - Orlova M
AU - Van Thuc N
AU - Ba NN
AU - Thai VH
AU - Abel L
AU - Schurr E
AU - Alcaïs A
AB - <p>A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.</p>
BT - The Journal of infectious diseases
C1 - http://www.ncbi.nlm.nih.gov/pubmed/22984114?dopt=Abstract
DA - 2012 Dec 01
DO - 10.1093/infdis/jis588
IS - 11
J2 - J. Infect. Dis.
LA - eng
N2 - <p>A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.</p>
PY - 2012
SP - 1763
EP - 7
T2 - The Journal of infectious diseases
TI - Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population.
VL - 206
SN - 1537-6613
ER -