TY - JOUR
KW - Animals
KW - Antigens, Bacterial
KW - BCG Vaccine
KW - Base Sequence
KW - DNA Primers
KW - leprosy
KW - Male
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Inbred C57BL
KW - Mycobacterium bovis
KW - Mycobacterium leprae
KW - Plasmids
KW - Spleen
KW - Vaccines, Synthetic
AU - Ohara N
AU - Matsuoka M
AU - Nomaguchi H
AU - Naito M
AU - Yamada T
AB - <p>The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than five times higher than parental BCG. Immunization of C57BL/6 and BALB/c mice with this rBCG reduced the multiplication of Mycobacterium leprae in the foot pads of both strains of mice. The inhibition by rBCG/BA51 was more evident than that by parental BCG.</p>
BT - Vaccine
C1 - http://www.ncbi.nlm.nih.gov/pubmed/11228360?dopt=Abstract
DA - 2001 Feb 28
DO - 10.1016/s0264-410x(00)00439-4
IS - 15-16
J2 - Vaccine
LA - eng
N2 - <p>The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than five times higher than parental BCG. Immunization of C57BL/6 and BALB/c mice with this rBCG reduced the multiplication of Mycobacterium leprae in the foot pads of both strains of mice. The inhibition by rBCG/BA51 was more evident than that by parental BCG.</p>
PY - 2001
SP - 1906
EP - 10
T2 - Vaccine
TI - Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates.
VL - 19
SN - 0264-410X
ER -