Leprosy is a chronic granulomatous disease caused by the bacillus Mycobacterium leprae. It primarily affects the skin and peripheral nerves and is still endemic in various regions of the world. Clinical presentation depends on the patient's immune status at the time of infection and during the course of the disease. Leprosy is associated with disability and marginalization. Diagnosis is clinical and is made when the patient has at least 1 of the following cardinal signs specified by the World Health Organization: hypopigmented or erythematous macules with sensory loss; thickened peripheral nerves; or positive acid-fast skin smear or skin biopsy with loss of adnexa at affected sites. Leprosy is treated with a multidrug combination of rifampicin, clofazimine, and dapsone. Two main regimens are used depending on whether the patient has paucibacillary or multibacillary disease. Copyright © 2011 Elsevier España, S.L. y AEDV. All rights reserved.
BT - Actas dermo-sifiliográficas C1 -http://www.ncbi.nlm.nih.gov/pubmed/22632796?dopt=Abstract
C2 - Spain CN - EICHELMANN 2012 CY - Madrid DA - 05/2012 DO - 10.1016/j.ad.2012.03.003 J2 - Actas Dermosifiliogr LA - spa N2 -Leprosy is a chronic granulomatous disease caused by the bacillus Mycobacterium leprae. It primarily affects the skin and peripheral nerves and is still endemic in various regions of the world. Clinical presentation depends on the patient's immune status at the time of infection and during the course of the disease. Leprosy is associated with disability and marginalization. Diagnosis is clinical and is made when the patient has at least 1 of the following cardinal signs specified by the World Health Organization: hypopigmented or erythematous macules with sensory loss; thickened peripheral nerves; or positive acid-fast skin smear or skin biopsy with loss of adnexa at affected sites. Leprosy is treated with a multidrug combination of rifampicin, clofazimine, and dapsone. Two main regimens are used depending on whether the patient has paucibacillary or multibacillary disease. Copyright © 2011 Elsevier España, S.L. y AEDV. All rights reserved.
PB - Elsevier España PP - Madrid PY - 2012 T2 - Actas dermo-sifiliográficas TI - [Leprosy. An Update: Definition, Pathogenesis, Classification, Diagnosis, and Treatment] TT - Lepra: puesta al día. Definición, patogénesis, clasificación, diagnóstico y tratamiento UR - http://apps.elsevier.es/watermark/ctl_servlet?_f=10&pident_articulo=15002&pident_usuario=0&pcontactid=&pident_revista=103&ty=125&accion=L&origen=elsevier&web=www.elsevier.es&lan=es&fichero=S0001-7310(12)00154-8.pdf&eop=1 SN - 1578-2190 ER -