TY - JOUR
KW - Autoimmunity
KW - Humans
KW - leprosy
KW - Melanocytes
KW - Melanoma
KW - Skin
KW - Symbiosis
KW - Vitiligo
AU - Das P K
AU - Wijngaard R M
AU - Wankowicz-Kalinska A
AU - Le Poole I C
AB - <p>Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.</p>
BT - Trends in immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/11286727?dopt=Abstract
DA - 2001 Mar
IS - 3
J2 - Trends Immunol.
LA - eng
N2 - <p>Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.</p>
PY - 2001
SP - 130
EP - 6
T2 - Trends in immunology
TI - A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo.
VL - 22
SN - 1471-4906
ER -