TY - JOUR
KW - Adult
KW - Apoptosis
KW - Caspase 3
KW - Female
KW - Humans
KW - leprosy
KW - Male
KW - Middle Aged
KW - Mycobacterium leprae
KW - Skin
KW - Transforming Growth Factor beta
AU - Quaresma JAS
AU - Almeida FAC
AU - Aarão TLS
AU - Soares LPMA
AU - Nunes Magno IM
AU - Fuzii HT
AU - Libonati RMF
AU - Xavier MB
AU - Pagliari C
AU - Duarte MIS
AB - <p>The course of leprosy depends of the host immune response which ranges from the lepromatous pole (LL) to the tuberculoid pole (TT). A comparative study was conducted in 60 patients with the LL and TT. The results showed a mean expression of TGF-β of 339 ± 99.4 cells/field for TT and of 519.2 ± 68.2 cells/field for LL. Frequency of apoptosis was 6.3 ± 1.8 in TT and 14.0 ± 6.1 in LL. A correlation (p = 0.0251) between TGF-β and caspase-3 in the LL was found. This finding indicates a role of TGF-β and apoptosis in the immune response in leprosy.</p>
BT - Microbes and infection
C1 - http://www.ncbi.nlm.nih.gov/pubmed/22429842?dopt=Abstract
C2 - France; USA
CY - Paris; New York
DA - 2012 Aug
DO - 10.1016/j.micinf.2012.02.010
IS - 9
J2 - Microbes Infect.
LA - eng
N2 - <p>The course of leprosy depends of the host immune response which ranges from the lepromatous pole (LL) to the tuberculoid pole (TT). A comparative study was conducted in 60 patients with the LL and TT. The results showed a mean expression of TGF-β of 339 ± 99.4 cells/field for TT and of 519.2 ± 68.2 cells/field for LL. Frequency of apoptosis was 6.3 ± 1.8 in TT and 14.0 ± 6.1 in LL. A correlation (p = 0.0251) between TGF-β and caspase-3 in the LL was found. This finding indicates a role of TGF-β and apoptosis in the immune response in leprosy.</p>
PB - Elsevier
PP - Paris; New York
PY - 2012
SP - 696
EP - 701
T2 - Microbes and infection
TI - Transforming growth factor β and apoptosis in leprosy skin lesions: possible relationship with the control of the tissue immune response in the Mycobacterium leprae infection.
VL - 14
SN - 1769-714X
ER -