TY - JOUR
KW - Adrenal Cortex Hormones
KW - Cyclosporine
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Middle Aged
KW - Pulmonary Embolism
KW - Radiography
KW - Thalidomide
KW - Treatment Outcome
KW - Venous Thrombosis
KW - Warfarin
AU - Yamaguchi S
AU - Yamamoto Y
AU - Hosokawa A
AU - Hagiwara K
AU - Uezato H
AU - Takahashi K
AB - <p>A 58-year-old Japanese man with a 2-year history of multidrug therapy for borderline lepromatous leprosy presented with skin lesions suggestive of erythema nodosum leprosum (ENL) and was treated with an oral corticosteroid. As attempts to taper the oral corticosteroid resulted in the appearance of new lesions, thalidomide was added along with cyclosporin. Two months after the introduction of thalidomide, deep venous thrombosis (DVT) occurred in both legs and anticoagulant therapy was started without cessation of thalidomide. Pulmonary embolism developed 1 month after the appearance of DVT, and these thromboembolic events were believed to be due to thalidomide. This case highlights the need for vigilance against venous thromboembolism when corticosteroid and thalidomide are co-administrated for the treatment of ENL.</p>
BT - The Journal of dermatology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/22373000?dopt=Abstract
C2 - UK
CY - London
DA - 2012 Aug
DO - 10.1111/j.1346-8138.2011.01484.x
IS - 8
J2 - J. Dermatol.
LA - eng
N2 - <p>A 58-year-old Japanese man with a 2-year history of multidrug therapy for borderline lepromatous leprosy presented with skin lesions suggestive of erythema nodosum leprosum (ENL) and was treated with an oral corticosteroid. As attempts to taper the oral corticosteroid resulted in the appearance of new lesions, thalidomide was added along with cyclosporin. Two months after the introduction of thalidomide, deep venous thrombosis (DVT) occurred in both legs and anticoagulant therapy was started without cessation of thalidomide. Pulmonary embolism developed 1 month after the appearance of DVT, and these thromboembolic events were believed to be due to thalidomide. This case highlights the need for vigilance against venous thromboembolism when corticosteroid and thalidomide are co-administrated for the treatment of ENL.</p>
PB - Blackwell Publishing Ltd
PP - London
PY - 2012
SP - 711
EP - 4
T2 - The Journal of dermatology
TI - Deep venous thrombosis and pulmonary embolism secondary to co-administration of thalidomide and oral corticosteroid in a patient with leprosy.
VL - 39
SN - 1346-8138
ER -