TY - JOUR KW - Animals KW - Dapsone KW - Diet KW - Female KW - leprosy KW - Male KW - Microbial Sensitivity Tests KW - Mycobacterium leprae KW - Rats AU - Peters J H AU - Gordon G R AU - Murray J F AU - Fieldsteel A H AU - Levy L AB -

To define the minimal inhibitory concentration (MIC) of dapsone (DDS) for Mycobacterium leprae in rats, we determined the relationship between dietary and plasma levels of DDS in uninfected male and female Lewis rats. This knowledge was applied to the design of experiments using rats inoculated in the footpads with M. leprae. The MIC for DDS in male and female rats, respectively, was 1.5 to 4.0 ng and 1.8 to 3.0 ng of DDS/ml of plasma, even though the sexes exhibited markedly different concentrations of DDS when receiving the same dietary level of DDS. These values for the MIC of DDS for M. leprae in rats are nearly identical to the previously determined MIC of DDS for M. leprae in mice.

BT - Antimicrobial agents and chemotherapy C1 - http://www.ncbi.nlm.nih.gov/pubmed/1108776?dopt=Abstract DA - 1975 Nov DO - 10.1128/aac.8.5.551 IS - 5 J2 - Antimicrob. Agents Chemother. LA - eng N2 -

To define the minimal inhibitory concentration (MIC) of dapsone (DDS) for Mycobacterium leprae in rats, we determined the relationship between dietary and plasma levels of DDS in uninfected male and female Lewis rats. This knowledge was applied to the design of experiments using rats inoculated in the footpads with M. leprae. The MIC for DDS in male and female rats, respectively, was 1.5 to 4.0 ng and 1.8 to 3.0 ng of DDS/ml of plasma, even though the sexes exhibited markedly different concentrations of DDS when receiving the same dietary level of DDS. These values for the MIC of DDS for M. leprae in rats are nearly identical to the previously determined MIC of DDS for M. leprae in mice.

PY - 1975 SP - 551 EP - 7 T2 - Antimicrobial agents and chemotherapy TI - Minimal inhibitory concentration of dapsone for Mycobacterium leprae in rats. VL - 8 SN - 0066-4804 ER -