TY - JOUR
KW - Asian Continental Ancestry Group
KW - Chromosomes, Human
KW - Chromosomes, Human, Pair 2
KW - Family
KW - Female
KW - Genetic Linkage
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Humans
KW - leprosy
KW - Lod Score
KW - Male
KW - Pedigree
KW - Polymorphism, Single Nucleotide
AU - Yang Q
AU - Liu H
AU - Low H
AU - Wang H
AU - Yu Y
AU - Fu X
AU - Yu G
AU - Chen M
AU - Yan X
AU - Chen S
AU - Huang W
AU - Liu J
AU - Zhang F
AB - <p><b>BACKGROUND: </b>A genetic component to the etiology of leprosy is well recognized but the mechanism of inheritance and the genes involved are yet to be fully established.</p><p><b>METHODOLOGY: </b>A genome-wide single nucleotide polymorphism (SNP) based linkage analysis was carried out using 23 pedigrees, each with 3 to 7 family members affected by leprosy. Multipoint parametric and non-parametric linkage analyses were performed using MERLIN 1.1.1.</p><p><b>PRINCIPAL FINDINGS: </b>Genome-wide significant evidence for linkage was identified on chromosome 2p14 with a heterogeneity logarithm of odds (HLOD) score of 3.51 (rs1106577) under a recessive model of inheritance, while suggestive evidence was identified on chr.4q22 (HLOD 2.92, rs1349350, dominant model), chr. 8q24 (HLOD 2.74, rs1618523, recessive model) and chr.16q24 (HLOD 1.93, rs276990 dominant model). Our study also provided moderate evidence for a linkage locus on chromosome 6q24-26 by non-parametric linkage analysis (rs6570858, LOD 1.54, p = 0.004), overlapping a previously reported linkage region on chromosome 6q25-26.</p><p><b>CONCLUSION: </b>A genome-wide linkage analysis has identified a new linkage locus on chromosome 2p14 for leprosy in Pedigrees from China.</p>
BT - PloS one
C1 - http://www.ncbi.nlm.nih.gov/pubmed/22238647?dopt=Abstract
C2 - USA
CY - San Francisco
DA - 2012
DO - 10.1371/journal.pone.0029747
IS - 1
J2 - PLoS ONE
LA - eng
N2 - <p><b>BACKGROUND: </b>A genetic component to the etiology of leprosy is well recognized but the mechanism of inheritance and the genes involved are yet to be fully established.</p><p><b>METHODOLOGY: </b>A genome-wide single nucleotide polymorphism (SNP) based linkage analysis was carried out using 23 pedigrees, each with 3 to 7 family members affected by leprosy. Multipoint parametric and non-parametric linkage analyses were performed using MERLIN 1.1.1.</p><p><b>PRINCIPAL FINDINGS: </b>Genome-wide significant evidence for linkage was identified on chromosome 2p14 with a heterogeneity logarithm of odds (HLOD) score of 3.51 (rs1106577) under a recessive model of inheritance, while suggestive evidence was identified on chr.4q22 (HLOD 2.92, rs1349350, dominant model), chr. 8q24 (HLOD 2.74, rs1618523, recessive model) and chr.16q24 (HLOD 1.93, rs276990 dominant model). Our study also provided moderate evidence for a linkage locus on chromosome 6q24-26 by non-parametric linkage analysis (rs6570858, LOD 1.54, p = 0.004), overlapping a previously reported linkage region on chromosome 6q25-26.</p><p><b>CONCLUSION: </b>A genome-wide linkage analysis has identified a new linkage locus on chromosome 2p14 for leprosy in Pedigrees from China.</p>
PB - Public Library of Science
PP - San Francisco
PY - 2012
EP - e29747
T2 - PloS one
TI - Chromosome 2p14 is linked to susceptibility to leprosy.
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253103/?tool=pubmed
VL - 7
SN - 1932-6203
ER -