TY - JOUR
KW - Case-Control Studies
KW - Cohort Studies
KW - Cytokines
KW - Genetic Predisposition to Disease
KW - Genetic Variation
KW - Haplotypes
KW - Host-Pathogen Interactions
KW - Humans
KW - India
KW - leprosy
KW - Linkage Disequilibrium
KW - Logistic Models
KW - Mycobacterium leprae
KW - Polymorphism, Single Nucleotide
KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
AU - Aggarwal S
AU - Ali S
AU - Chopra R
AU - Srivastava AK
AU - Kalaiarasan P
AU - Malhotra D
AU - Gochhait S
AU - Garg V
AU - Bhattacharya S N
AU - Bamezai R
AB - <p><b>BACKGROUND: </b>Mycobacterium leprae is the etiologic pathogen that causes leprosy. The outcome of disease is dependent on the host genetic background.</p><p><b>METHODS: </b>We investigated the association of 51 single-nucelotide polymorphisms (SNPs) in anti-inflammatory cytokines (IL-10, TGFB1, IL-6, IL-4, and IL-13) and receptors (IL-10RA, IL-10RB, TGFBR1, TGFBR2, IL-6R, IL-4R, IL-5RA, IL-5RB, and IL-13RA1) with susceptibility to leprosy in a case-control study from New Delhi in northern India. This was followed by replication testing of associated SNPs in a geographically distinct and unrelated population from Orissa in eastern India. The functional potential of SNPs was established with in vitro reporter assays.</p><p><b>RESULTS: </b>Significant associations (P < .05) were observed for 8 polymorphisms (rs1800871, rs1800872, and rs1554286 of IL-10; rs3171425 and rs7281762 of IL-10RB; rs2228048 and rs744751 of TGFBR2; and rs1800797 of IL-6) with leprosy. This association was replicated for 4 SNPs (rs1554286 of IL-10, rs7281762 of IL-10RB, rs2228048 of TGFBR2, and rs1800797 of IL-6). The interaction study revealed a significantly greater association with leprosy risk than was obtained for any SNP individually.</p><p><b>CONCLUSIONS: </b>This study provides an interesting insight on the cumulative polygenic host component that regulates leprosy pathogenesis.</p>
BT - The Journal of infectious diseases
C1 - http://www.ncbi.nlm.nih.gov/pubmed/21917900?dopt=Abstract
C2 - UK
CY -  Oxford 
DA - 2011 Oct 15
DO - 10.1093/infdis/jir516
IS - 8
J2 - J. Infect. Dis.
LA - eng
N2 - <p><b>BACKGROUND: </b>Mycobacterium leprae is the etiologic pathogen that causes leprosy. The outcome of disease is dependent on the host genetic background.</p><p><b>METHODS: </b>We investigated the association of 51 single-nucelotide polymorphisms (SNPs) in anti-inflammatory cytokines (IL-10, TGFB1, IL-6, IL-4, and IL-13) and receptors (IL-10RA, IL-10RB, TGFBR1, TGFBR2, IL-6R, IL-4R, IL-5RA, IL-5RB, and IL-13RA1) with susceptibility to leprosy in a case-control study from New Delhi in northern India. This was followed by replication testing of associated SNPs in a geographically distinct and unrelated population from Orissa in eastern India. The functional potential of SNPs was established with in vitro reporter assays.</p><p><b>RESULTS: </b>Significant associations (P < .05) were observed for 8 polymorphisms (rs1800871, rs1800872, and rs1554286 of IL-10; rs3171425 and rs7281762 of IL-10RB; rs2228048 and rs744751 of TGFBR2; and rs1800797 of IL-6) with leprosy. This association was replicated for 4 SNPs (rs1554286 of IL-10, rs7281762 of IL-10RB, rs2228048 of TGFBR2, and rs1800797 of IL-6). The interaction study revealed a significantly greater association with leprosy risk than was obtained for any SNP individually.</p><p><b>CONCLUSIONS: </b>This study provides an interesting insight on the cumulative polygenic host component that regulates leprosy pathogenesis.</p>
PB - Oxford University Press
PP -  Oxford 
PY - 2011
SP - 1264
EP - 73
T2 - The Journal of infectious diseases
TI - Genetic variations and interactions in anti-inflammatory cytokine pathway genes in the outcome of leprosy: a study conducted on a MassARRAY platform.
VL - 204
SN - 1537-6613
ER -