TY - JOUR
KW - Bacterial Proteins
KW - Dapsone
KW - Humans
KW - India
KW - Leprostatic Agents
KW - leprosy
KW - Molecular Epidemiology
KW - Mutation
KW - Mycobacterium leprae
KW - Philippines
KW - Rifampin
AU - Li W
AU - Sakamuri R
AU - Lyons DE
AU - Orcullo FM
AU - Shinde V
AU - Dela Pena EL
AU - Maghanoy AA
AU - Mallari I
AU - Tan E
AU - Nath I
AU - Brennan PJ
AU - Balagon M
AU - Vissa V
AB - <p>Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target gene rpoB. These findings indicate that dapsone resistance is being transmitted.</p>
BT - Antimicrobial agents and chemotherapy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/21859943?dopt=Abstract
CY - Washington
DA - 2011 Nov
DO - 10.1128/AAC.05236-11
IS - 11
J2 - Antimicrob. Agents Chemother.
LA - eng
N2 - <p>Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target gene rpoB. These findings indicate that dapsone resistance is being transmitted.</p>
PB -  American Society for Microbiology
PP - Washington
PY - 2011
SP - 5384
EP - 7
T2 - Antimicrobial agents and chemotherapy
TI - Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.
VL - 55
SN - 1098-6596
ER -