TY - JOUR
KW - Africa, Western
KW - Animals
KW - Antibodies, Bacterial
KW - Antigens, Bacterial
KW - Ape Diseases
KW - Biomarkers
KW - Diagnosis, Differential
KW - Glycolipids
KW - leprosy
KW - Mycobacterium leprae
KW - Pan troglodytes
KW - polymerase chain reaction
KW - Polymorphism, Single Nucleotide
KW - Zoonoses
AU - Ishii N
AU - Udono T
AU - Fujisawa M
AU - Idani G
AU - Tanigawa K
AU - Miyamura T
AU - Suzuki K
AB - <p>Leprosy is suspected to develop after a long period of latency following infection with Mycobacterium leprae (M. leprae) during infancy, but definitive proof has been lacking. We found a rare case of leprosy in a chimpanzee (Pan troglodytes) born in West Africa (Sierra Leone) and brought to Japan around 2 years of age. At 31, the ape started exhibiting pathognomic signs of leprosy. Pathological diagnosis, skin smear, serum anti-phenolic glycolipid-I (PGL-I) antibody, and by PCR analysis demonstrated lepromatous leprosy. Single-nucleotide polymorphism (SNP) analysis verified the West African origin of the bacilli. This occurrence suggests the possibility of leprosy being endemic among wild chimpanzees in West Africa, potentially posing a zoonotic risk.</p>
BT - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/21404593?dopt=Abstract
C2 - Japan

CY - Higashimurayama-shi 
DA - 2011 Feb
IS - 1
J2 - Nihon Hansenbyo Gakkai Zasshi
LA - jpn
N2 - <p>Leprosy is suspected to develop after a long period of latency following infection with Mycobacterium leprae (M. leprae) during infancy, but definitive proof has been lacking. We found a rare case of leprosy in a chimpanzee (Pan troglodytes) born in West Africa (Sierra Leone) and brought to Japan around 2 years of age. At 31, the ape started exhibiting pathognomic signs of leprosy. Pathological diagnosis, skin smear, serum anti-phenolic glycolipid-I (PGL-I) antibody, and by PCR analysis demonstrated lepromatous leprosy. Single-nucleotide polymorphism (SNP) analysis verified the West African origin of the bacilli. This occurrence suggests the possibility of leprosy being endemic among wild chimpanzees in West Africa, potentially posing a zoonotic risk.</p>
PB - Nihon Hansenbyō Gakkai
PP - Higashimurayama-shi 
PY - 2011
SP - 29
EP - 36
T2 - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
TI - [Leprosy in a chimpanzee].
VL - 80
SN - 1342-3681
ER -