Relapse rates after multiple-drug therapy (MDT) have been low, although there remains a concern about the possibility of late relapse in those with an initially high bacterial load. In all, 502 patients in the AMFES cohort completed fixed-duration MDT and are included in this report. There have been no confirmed relapses in the AMFES cohort, in a follow-up period of up to 8 years after completion of treatment, even in the 57 cases with an initial average bacillary index of > or = 4.0, 20 of whom have been followed for more than 5 years after ceasing MDT. Methods of diagnosing a relapse are discussed.
BT - Leprosy review C1 - http://www.ncbi.nlm.nih.gov/pubmed/11105491?dopt=Abstract CN - Infolep Library - available DA - 2000 Sep DO - 10.5935/0305-7518.20000036 IS - 3 J2 - Lepr Rev LA - eng N2 -Relapse rates after multiple-drug therapy (MDT) have been low, although there remains a concern about the possibility of late relapse in those with an initially high bacterial load. In all, 502 patients in the AMFES cohort completed fixed-duration MDT and are included in this report. There have been no confirmed relapses in the AMFES cohort, in a follow-up period of up to 8 years after completion of treatment, even in the 57 cases with an initial average bacillary index of > or = 4.0, 20 of whom have been followed for more than 5 years after ceasing MDT. Methods of diagnosing a relapse are discussed.
PY - 2000 SP - 325 EP - 31 T2 - Leprosy review TI - Relapses after fixed duration multiple drug therapy: the AMFES cohort. UR - http://leprev.ilsl.br/pdfs/2000/v71n3/pdf/v71n3a12.pdf VL - 71 SN - 0305-7518 ER -