TY - JOUR
KW - Adolescent
KW - Adult
KW - Asian Continental Ancestry Group
KW - Case-Control Studies
KW - Child
KW - Child, Preschool
KW - Female
KW - Genetic Predisposition to Disease
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Interleukin-4
KW - leprosy
KW - Male
KW - Middle Aged
KW - polymerase chain reaction
KW - Polymorphism, Genetic
KW - Polymorphism, Restriction Fragment Length
KW - Young Adult
AU - Yang D
AU - Song H
AU - Xu W
AU - Long H
AU - Shi C
AU - Jing Z
AU - Song W
AU - Pei B
AB - <p><b>BACKGROUND: </b>Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Cell-mediated (Th1) immune response and humoral (Th2) immune response play different roles in leprosy infection. Interleukin 4 (IL-4) is a typical Th2 cytokine. It is a critical mediator of the Th1/Th2 balance.</p><p><b>OBJECTIVE: </b>The objective of this study is to investigate the association between IL-4 gene -590T/C polymorphism and the susceptibility to leprosy in a Chinese population.</p><p><b>METHODS: </b>The IL-4 variant -590T/C was detected by polymerase chain reaction-restriction fragment length polymorphism in 432 leprosy cases and 465 age-matched healthy controls. Data were analyzed using the chi-square test.</p><p><b>RESULTS: </b>Frequencies of the IL-4-590TC and CC genotypes and the -590C allele were significantly lower in patients with leprosy than in healthy controls (odds ratio [OR]=0.74, 95% confidence interval [CI] 0.55-0.99, p=0.044; OR=0.46, 95% CI 0.25-0.84, p=0.010; and OR=0.68, 95% CI 0.54-0.86, p=0.001, respectively).</p><p><b>CONCLUSIONS: </b>Our data suggest that the -590T/C polymorphism of the IL-4 gene is associated with decreased susceptibility of leprosy.</p>
BT - Genetic testing and molecular biomarkers
C1 - http://www.ncbi.nlm.nih.gov/pubmed/21749213?dopt=Abstract
DA - 2011 Dec
DO - 10.1089/gtmb.2011.0032
IS - 12
J2 - Genet Test Mol Biomarkers
LA - eng
N2 - <p><b>BACKGROUND: </b>Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Cell-mediated (Th1) immune response and humoral (Th2) immune response play different roles in leprosy infection. Interleukin 4 (IL-4) is a typical Th2 cytokine. It is a critical mediator of the Th1/Th2 balance.</p><p><b>OBJECTIVE: </b>The objective of this study is to investigate the association between IL-4 gene -590T/C polymorphism and the susceptibility to leprosy in a Chinese population.</p><p><b>METHODS: </b>The IL-4 variant -590T/C was detected by polymerase chain reaction-restriction fragment length polymorphism in 432 leprosy cases and 465 age-matched healthy controls. Data were analyzed using the chi-square test.</p><p><b>RESULTS: </b>Frequencies of the IL-4-590TC and CC genotypes and the -590C allele were significantly lower in patients with leprosy than in healthy controls (odds ratio [OR]=0.74, 95% confidence interval [CI] 0.55-0.99, p=0.044; OR=0.46, 95% CI 0.25-0.84, p=0.010; and OR=0.68, 95% CI 0.54-0.86, p=0.001, respectively).</p><p><b>CONCLUSIONS: </b>Our data suggest that the -590T/C polymorphism of the IL-4 gene is associated with decreased susceptibility of leprosy.</p>
PY - 2011
SP - 877
EP - 81
T2 - Genetic testing and molecular biomarkers
TI - Interleukin 4-590T/C polymorphism and susceptibility to leprosy.
VL - 15
SN - 1945-0257
ER -