TY - JOUR
KW - Autoinflammatory
KW - Erythema Nodosum Leprosum
KW - Reaction
KW - leprosy
AU - Quandelacy T
AU - Holtz M
AU - Franco-Paredes C
AB - There are two types of leprosy reactions: reversal reactions or type 1 and erythema nodosum leprosum or type 2. Deformity and disability
associated with leprosy are frequently the result of uncontrolled or untreated reactions. Although there is current availability of glucocorticoids
as the mainstay of therapy, much needs to be learned about the etiology, risk factors, and pathogenesis of leprosy reactions. There
is some evidence that leprosy reactions may represent, particularly, erythema nodosum leprosum autoinflammatory disease due to the
aberrant activation of the innate immune system. The role for herpesviruses influencing autophagy in macrophages needs to be evaluated
in the pathogenesis of leprosy reactions.
BT - Bol Med Hosp Infant Mex
IS - 2
J2 - Bol Med Hosp Infant Mex
LA - eng
N2 - There are two types of leprosy reactions: reversal reactions or type 1 and erythema nodosum leprosum or type 2. Deformity and disability
associated with leprosy are frequently the result of uncontrolled or untreated reactions. Although there is current availability of glucocorticoids
as the mainstay of therapy, much needs to be learned about the etiology, risk factors, and pathogenesis of leprosy reactions. There
is some evidence that leprosy reactions may represent, particularly, erythema nodosum leprosum autoinflammatory disease due to the
aberrant activation of the innate immune system. The role for herpesviruses influencing autophagy in macrophages needs to be evaluated
in the pathogenesis of leprosy reactions.
PY - 2011
SP - 127
EP - 129
T2 - Bol Med Hosp Infant Mex
TI - Are leprosy reactions autoinflammatory diseases?
UR - http://www.nietoeditores.com.mx/download/bol_med_HIM/MARZO-ABRIL%202011/BOL%20Med%20Hosp%20espa%C3%B1ol/Bol%20Med%20Hosp%202.10%20ARE.pdf
VL - 68
ER -