TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Child
KW - Child, Preschool
KW - Gene Frequency
KW - Genetic Predisposition to Disease
KW - genotype
KW - Histocompatibility Antigens Class I
KW - Humans
KW - India
KW - Infant
KW - leprosy
KW - Middle Aged
KW - Polymorphism, Single Nucleotide
KW - Vietnam
KW - Young Adult
AU - Alter A
AU - Huong NT
AU - Singh M
AU - Orlova M
AU - Van Thuc N
AU - Katoch K
AU - Gao X
AU - Thai VH
AU - Ba NN
AU - Carrington M
AU - Abel L
AU - Mehra N
AU - Alcaïs A
AU - Schurr E
AB - <p>Experimental evidence suggested the existence of unidentified leprosy susceptibility loci in the human leukocyte antigen (HLA) complex. To identify such genetic risk factors, a high-density association scan of a 1.9-mega-base (Mb) region in the HLA complex was performed. Among 682 single-nucleotide polymorphisms (SNPs), 59 were associated with leprosy (P <.01) in 198 Vietnamese single-case leprosy families. Genotyping of these SNPs in an independent sample of 292 Vietnamese single-case leprosy families replicated the association of 12 SNPs (P <.01). Multivariate analysis of these 12 SNPs showed that the association information could be captured by 2 intergenic HLA class I region SNPs (P = 9.4 × 10⁻⁹)-rs2394885 and rs2922997 (marginal multivariate P = 2.1 × 10⁻⁷ and P = .0016, respectively). SNP rs2394885 tagged the HLA-C*15:05 allele in the Vietnamese population. The identical associations were validated in a third sample of 364 patients with leprosy and 371 control subjects from North India. These results implicated class I alleles in leprosy pathogenesis.</p>
BT - The Journal of infectious diseases
C1 - http://www.ncbi.nlm.nih.gov/pubmed/21459816?dopt=Abstract
CN - ALTER 2011
DA - 2011 May 01
DO - 10.1093/infdis/jir024
IS - 9
J2 - J. Infect. Dis.
LA - eng
N2 - <p>Experimental evidence suggested the existence of unidentified leprosy susceptibility loci in the human leukocyte antigen (HLA) complex. To identify such genetic risk factors, a high-density association scan of a 1.9-mega-base (Mb) region in the HLA complex was performed. Among 682 single-nucleotide polymorphisms (SNPs), 59 were associated with leprosy (P <.01) in 198 Vietnamese single-case leprosy families. Genotyping of these SNPs in an independent sample of 292 Vietnamese single-case leprosy families replicated the association of 12 SNPs (P <.01). Multivariate analysis of these 12 SNPs showed that the association information could be captured by 2 intergenic HLA class I region SNPs (P = 9.4 × 10⁻⁹)-rs2394885 and rs2922997 (marginal multivariate P = 2.1 × 10⁻⁷ and P = .0016, respectively). SNP rs2394885 tagged the HLA-C*15:05 allele in the Vietnamese population. The identical associations were validated in a third sample of 364 patients with leprosy and 371 control subjects from North India. These results implicated class I alleles in leprosy pathogenesis.</p>
PY - 2011
SP - 1274
EP - 81
T2 - The Journal of infectious diseases
TI - Human leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and India.
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069725/pdf/jir024.pdf
VL - 203
SN - 1537-6613
ER -