TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Drug Resistance, Bacterial
KW - Female
KW - genotype
KW - Humans
KW - leprosy
KW - Male
KW - Microbial Sensitivity Tests
KW - Middle Aged
KW - Mycobacterium leprae
KW - Polymorphism, Single Nucleotide
KW - South America
AU - Singh P
AU - Busso P
AU - Paniz-Mondolfi A
AU - Aranzazu N
AU - Monot M
AU - Honore N
AU - Belone AFF
AU - Virmond M
AU - Villarreal-Olaya ME
AU - Rivas C
AU - Cole S
AB - <p>Possible drug resistance in Mycobacterium leprae strains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two of the three strains from relapsed cases contained dapsone resistance mutations, and one strain also harbored a rifampin resistance mutation. Single nucleotide polymorphism analysis of these strains revealed five subtypes: 3I (73.8%), 4P (11.6%), 1D (6.9%), 4N (6%), and 4O (1.7%).</p>
BT - Antimicrobial agents and chemotherapy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/21444694?dopt=Abstract
DA - 2011 Jun
DO - 10.1128/AAC.00201-11
IS - 6
J2 - Antimicrob. Agents Chemother.
LA - eng
N2 - <p>Possible drug resistance in Mycobacterium leprae strains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two of the three strains from relapsed cases contained dapsone resistance mutations, and one strain also harbored a rifampin resistance mutation. Single nucleotide polymorphism analysis of these strains revealed five subtypes: 3I (73.8%), 4P (11.6%), 1D (6.9%), 4N (6%), and 4O (1.7%).</p>
PY - 2011
SP - 2971
EP - 3
T2 - Antimicrobial agents and chemotherapy
TI - Molecular drug susceptibility testing and genotyping of Mycobacterium leprae strains from South America.
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101379/pdf/zac2971.pdf
VL - 55
SN - 1098-6596
ER -