TY - JOUR
KW - Adult
KW - Dose-Response Relationship, Drug
KW - Drug Administration Schedule
KW - Erythema Nodosum
KW - Female
KW - Humans
KW - Immunosuppressive Agents
KW - Leprostatic Agents
KW - Leprosy, lepromatous
KW - Male
KW - Middle Aged
KW - Necrosis
KW - Recurrence
KW - Skin
KW - Thalidomide
KW - Treatment Outcome
AU - Rattan R
AU - Shanker V
AU - Tegta G R
AU - Verma G K
AB - <p>Thalidomide, a racemic glutamic acid analogue, was first developed in 1954 and subsequently marketed in Europe, Australia and Canada as a sedative and anti-emetic. It was approved by the Food and Drug Administration (FDA) in the USA in 1998 for the treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL) and suppression of the cutaneous manifestations of ENL recurrences. It is a good choice for management in patients who are dependent on corticosteroids. Common side effects of thalidomide are teratogenicity, peripheral neuropathy, sedation and constipation. We report 4 cases of Hansen's disease with recurrent ENL who were adequately managed on thalidomide. On sudden withdrawal of thalidomide, they relapsed with severe type 2 reaction including necrotic ENL.</p>
BT - Indian journal of leprosy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/20704076?dopt=Abstract
DA - 2009 Oct-Dec
DO - 10.2340/16501977-0625
IS - 4
J2 - Indian J Lepr
LA - eng
N2 - <p>Thalidomide, a racemic glutamic acid analogue, was first developed in 1954 and subsequently marketed in Europe, Australia and Canada as a sedative and anti-emetic. It was approved by the Food and Drug Administration (FDA) in the USA in 1998 for the treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL) and suppression of the cutaneous manifestations of ENL recurrences. It is a good choice for management in patients who are dependent on corticosteroids. Common side effects of thalidomide are teratogenicity, peripheral neuropathy, sedation and constipation. We report 4 cases of Hansen's disease with recurrent ENL who were adequately managed on thalidomide. On sudden withdrawal of thalidomide, they relapsed with severe type 2 reaction including necrotic ENL.</p>
PY - 2009
SP - 199
EP - 203
T2 - Indian journal of leprosy
TI - Severe form of type 2 reaction in patients of Hansen's disease after withdrawal of thalidomide: case reports.
UR - http://www.ijl.org.in/PDF%20(Journal%20Oct-Dec%202009)/5_Abst%20(Severe%20form)199-203.pdf
VL - 81
SN - 0254-9395
ER -