In a study of 37 leprosy patients, the oral administration of levamisole failed to provoke an increase in both the Fernandez and Mitsuda reactions to lepromins of human and armadillo origin. We interpret this as evidence against an effective specific immunostimulatory capability of levamisole in leprosy patients under the conditions of the study. Current knowledge of the mechanism of levamisole action supports the concept that the fundamental immunologic defect in lepromatosus leprosy may reside in the lymphocyte and not the macrophage, or the respective related functions of these two cell forms.
BT - The American journal of tropical medicine and hygiene C1 - http://www.ncbi.nlm.nih.gov/pubmed/1103643?dopt=Abstract DA - 1975 Sep DO - 10.4269/ajtmh.1975.24.857 IS - 5 J2 - Am. J. Trop. Med. Hyg. LA - eng N2 -In a study of 37 leprosy patients, the oral administration of levamisole failed to provoke an increase in both the Fernandez and Mitsuda reactions to lepromins of human and armadillo origin. We interpret this as evidence against an effective specific immunostimulatory capability of levamisole in leprosy patients under the conditions of the study. Current knowledge of the mechanism of levamisole action supports the concept that the fundamental immunologic defect in lepromatosus leprosy may reside in the lymphocyte and not the macrophage, or the respective related functions of these two cell forms.
PY - 1975 SP - 857 EP - 9 T2 - The American journal of tropical medicine and hygiene TI - Failure of levamisole to alter the lepromin reaction. VL - 24 SN - 0002-9637 ER -