TY - JOUR
KW - Animals
KW - BCG Vaccine
KW - Carrier Proteins
KW - Cation Transport Proteins
KW - Genetic Linkage
KW - Genetic Markers
KW - Genetic Predisposition to Disease
KW - Humans
KW - Immunity, Innate
KW - leprosy
KW - Membrane Proteins
KW - Mice
KW - Tuberculosis, Pulmonary
KW - Urinary Bladder Neoplasms
AU - Buu N
AU - Sánchez F
AU - Schurr E
AB - <p>In the mouse, resistance and susceptibility to intracellular growth of mycobacteria in macrophages is controlled by the Bcg (Nramp1) gene, which has been cloned and shown to encode a macrophage phagosomal membrane protein with a putative transporter function. In the homologous human NRAMP1 gene, a total of 11 polymorphisms have been identified, which are being used to test for the linkage of NRAMP1 alleles with human responses to mycobacteria, including susceptibility to tuberculosis and leprosy, as well as BCG immunotherapy in bladder cancer.</p>
BT - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
C1 - http://www.ncbi.nlm.nih.gov/pubmed/11010829?dopt=Abstract
DA - 2000 Sep
DO - 10.1086/314067
J2 - Clin. Infect. Dis.
LA - eng
N2 - <p>In the mouse, resistance and susceptibility to intracellular growth of mycobacteria in macrophages is controlled by the Bcg (Nramp1) gene, which has been cloned and shown to encode a macrophage phagosomal membrane protein with a putative transporter function. In the homologous human NRAMP1 gene, a total of 11 polymorphisms have been identified, which are being used to test for the linkage of NRAMP1 alleles with human responses to mycobacteria, including susceptibility to tuberculosis and leprosy, as well as BCG immunotherapy in bladder cancer.</p>
PY - 2000
SP - S81
EP - 5
T2 - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
TI - The Bcg host-resistance gene.
VL - 31 Suppl 3
SN - 1058-4838
ER -