TY - JOUR
KW - Skin
KW - Mexico
KW - leprosy
KW - Drug Resistance
KW - DNA
KW - Dapsone
KW - Biopsy
KW - Analysis
AU - Lopez Roa R I
AU - Morris M F
AU - Matsuoka M
AB - A skin biopsy sample was obtained from a relapsed lepromatous leprosy patient from the central area of Mexico. Genes associated with resistance to anti-leprosy drugs were analyzed at codon 53 (ACC-->GCC) in de folP gene, which is known to confer dapsone resistance. No mutations in de rpoB and gyrA, which indicate resistance to rifampicin and floiriquinoles, were detected. This is the first case of dapsone resitant leprosy in Mexico in which the cause of the resistance is shown at genomic level. Evaluation of drug resistance by identifying known mutations in these genes by PCR is simple and reliable. Testing for resistance to anti-leprosy drugs should be performed in relapses or intractable cases for a better outcome.
BT - Revista Latinoamericana de Microbiologia
CN - LOPEZROA 2006
DA - 2006///
IS - 3-4
J2 - Rev.Latinoam.Microbiol.
LA - eng
N2 - A skin biopsy sample was obtained from a relapsed lepromatous leprosy patient from the central area of Mexico. Genes associated with resistance to anti-leprosy drugs were analyzed at codon 53 (ACC-->GCC) in de folP gene, which is known to confer dapsone resistance. No mutations in de rpoB and gyrA, which indicate resistance to rifampicin and floiriquinoles, were detected. This is the first case of dapsone resitant leprosy in Mexico in which the cause of the resistance is shown at genomic level. Evaluation of drug resistance by identifying known mutations in these genes by PCR is simple and reliable. Testing for resistance to anti-leprosy drugs should be performed in relapses or intractable cases for a better outcome.
PY - 2006
SP - 256 
EP -  259
T2 - Revista Latinoamericana de Microbiologia
TI - A drug resistant leprosy case detected by DNA sequence analysis from a relapsed Mexican leprosy patient
UR - http://www.medigraphic.com/pdfs/lamicro/mi-2006/mi063_4d.pdf
VL - 48
ER -