Serum immunoglobulins G, A, and M were estimated in 14 patients with border-line cases of leprosy at commencement of treatment and subsequently when they developed 'reversal reaction'. There was a significant increase in all immunoglobulin levels during the reaction, with a subsequent fall; the postreaction values for IgG and IgA were below the base-line figures. Additonal investigations in six patients indicated that the rise was a nonspecific one, not brought about by an increase in antimycobacterial antibodies. It seems likely that the rise in immunoglobulins during reaction is due to nonspecific T-lymphocyte stimulation of B lymphocytes.
BT - Scandinavian journal of immunology C1 - http://www.ncbi.nlm.nih.gov/pubmed/1084018?dopt=Abstract DA - 1976 DO - 10.1111/j.1365-3083.1976.tb00280.x IS - 3 J2 - Scand. J. Immunol. LA - eng N2 -Serum immunoglobulins G, A, and M were estimated in 14 patients with border-line cases of leprosy at commencement of treatment and subsequently when they developed 'reversal reaction'. There was a significant increase in all immunoglobulin levels during the reaction, with a subsequent fall; the postreaction values for IgG and IgA were below the base-line figures. Additonal investigations in six patients indicated that the rise was a nonspecific one, not brought about by an increase in antimycobacterial antibodies. It seems likely that the rise in immunoglobulins during reaction is due to nonspecific T-lymphocyte stimulation of B lymphocytes.
PY - 1976 SP - 287 EP - 91 T2 - Scandinavian journal of immunology TI - Does nonspecific T-lymphocyte stimulation of B lymphocytes occur during reversal reaction in borderline leprosy? VL - 5 SN - 0300-9475 ER -