TY - JOUR
KW - Alleles
KW - Carrier Proteins
KW - Cation Transport Proteins
KW - Female
KW - Genetic Linkage
KW - Genetic Predisposition to Disease
KW - Humans
KW - leprosy
KW - Lod Score
KW - Male
KW - Membrane Proteins
KW - Microsatellite Repeats
KW - Pedigree
KW - polymerase chain reaction
KW - Polymorphism, Genetic
KW - Polynesia
AU - Roger M
AU - Levee G
AU - Chanteau S
AU - Gicquel B
AU - Schurr E
AB - <p>In order to determine whether a human homolog (NRAMP1) to a murine candidate gene for resistance to mycobacteria influences susceptibility to human disease, we analyzed data from seven multicase leprosy families (84 individuals) from French Polynesia for linkage markers within the NRAMP1 gene and leprosy per se. Individual family members were typed at nine polymorphic loci within NRAMP1. In addition, three physically linked, polymorphic microsatellite markers-D2S104, D2S173 and D2S1471-were also typed. Linkage analyses were done using affected sibpair and LOD score methods employing different modes of inheritance with full and reduced penetrance. The results of this study strongly suggest that NRAMP1 is not linked to leprosy susceptibility in the French Polynesian families tested.</p>

BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - <p>http://www.ncbi.nlm.nih.gov/pubmed/9251591?dopt=Abstract</p>

DA - 1997 Jun
IS - 2
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>In order to determine whether a human homolog (NRAMP1) to a murine candidate gene for resistance to mycobacteria influences susceptibility to human disease, we analyzed data from seven multicase leprosy families (84 individuals) from French Polynesia for linkage markers within the NRAMP1 gene and leprosy per se. Individual family members were typed at nine polymorphic loci within NRAMP1. In addition, three physically linked, polymorphic microsatellite markers-D2S104, D2S173 and D2S1471-were also typed. Linkage analyses were done using affected sibpair and LOD score methods employing different modes of inheritance with full and reduced penetrance. The results of this study strongly suggest that NRAMP1 is not linked to leprosy susceptibility in the French Polynesian families tested.</p>

PY - 1997
SP - 197
EP - 202
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - No evidence for linkage between leprosy susceptibility and the human natural resistance-associated macrophage protein 1 (NRAMP1) gene in French Polynesia.
UR - http://ila.ilsl.br/pdfs/v65n2a06.pdf
VL - 65
SN - 0148-916X
ER -