TY - JOUR
KW - Adult
KW - Biotransformation
KW - Chromatography, High Pressure Liquid
KW - Chromatography, Thin Layer
KW - Clofazimine
KW - Humans
KW - Leprostatic Agents
KW - Liver
KW - Male
KW - Mass Spectrometry
AU - Krishna D R
AU - Mamidi R N
AU - Hofmann U
AU - Prabhakar C M
AB - <p>Clofazimine (CAS 2030-63-9) is an important drug used in the treatment of leprosy. Its important metabolites are investigated by thin layer chromatography (TLC), HPLC (diode array) and HPLC-electrospray mass spectrometry. The resulting analytical data, extraction, isolation and characterization methods are presented. Their applicability is described for human urine analysis.</p>
BT - Arzneimittel-Forschung
C1 - http://www.ncbi.nlm.nih.gov/pubmed/9105550?dopt=Abstract
DA - 1997 Mar
IS - 3
J2 - Arzneimittelforschung
LA - eng
N2 - <p>Clofazimine (CAS 2030-63-9) is an important drug used in the treatment of leprosy. Its important metabolites are investigated by thin layer chromatography (TLC), HPLC (diode array) and HPLC-electrospray mass spectrometry. The resulting analytical data, extraction, isolation and characterization methods are presented. Their applicability is described for human urine analysis.</p>
PY - 1997
SP - 303
EP - 6
T2 - Arzneimittel-Forschung
TI - Characterization of clofazimine metabolites in humans by HPLC-electrospray mass spectrometry.
VL - 47
SN - 0004-4172
ER -