TY - JOUR KW - Acute disease KW - Adolescent KW - Anti-Inflammatory Agents KW - Dapsone KW - Drug Hypersensitivity KW - Female KW - Hepatitis E KW - Humans KW - Leprostatic Agents KW - leprosy KW - Prednisolone KW - Syndrome AU - Chogle A AU - Nagral A AU - Soni A AU - Agale S AU - Jamadar Z AB -
A 14-year-old girl presented with fever, generalized lymphadenopathy, skin rash and hepatitis after starting dapsone. All abnormalities reversed with institution of prednisolone therapy after discontinuation of dapsone. The hepatic involvement was of hepatocellular type; it was associated with IgM anti-HEV antibodies, suggesting coexisting acute hepatitis E. We believe a causal link between the hepatotrophic viruses and dapsone hypersensitivity syndrome could exist.
BT - Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology C1 - http://www.ncbi.nlm.nih.gov/pubmed/10812824?dopt=Abstract DA - 2000 Apr-Jun IS - 2 J2 - Indian J Gastroenterol LA - eng N2 -A 14-year-old girl presented with fever, generalized lymphadenopathy, skin rash and hepatitis after starting dapsone. All abnormalities reversed with institution of prednisolone therapy after discontinuation of dapsone. The hepatic involvement was of hepatocellular type; it was associated with IgM anti-HEV antibodies, suggesting coexisting acute hepatitis E. We believe a causal link between the hepatotrophic viruses and dapsone hypersensitivity syndrome could exist.
PY - 2000 SP - 85 EP - 6 T2 - Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology TI - Dapsone hypersensitivity syndrome with coexisting acute hepatitis E. VL - 19 SN - 0254-8860 ER -