A case of agranulocytosis due to dapsone administered for the treatment of acne vulgaris is described. Agranulocytosis has previously been reported after administration of dapsone for other dermatological disorders, leprosy, and prophylaxis against falciparum malaria. The frequency of agranulocytoses when dapsone was used for malaria prophylaxis in United States servicemen in Vietnam was sufficient to result in its withdrawal from use for this purpose. Caution should therefore be exercised in the administration of dapsone for conditions for which less toxic agents are available.
BT - The Medical journal of Australia C1 - http://www.ncbi.nlm.nih.gov/pubmed/909500?dopt=Abstract DA - 1977 Aug 20 IS - 8 J2 - Med. J. Aust. LA - eng N2 -A case of agranulocytosis due to dapsone administered for the treatment of acne vulgaris is described. Agranulocytosis has previously been reported after administration of dapsone for other dermatological disorders, leprosy, and prophylaxis against falciparum malaria. The frequency of agranulocytoses when dapsone was used for malaria prophylaxis in United States servicemen in Vietnam was sufficient to result in its withdrawal from use for this purpose. Caution should therefore be exercised in the administration of dapsone for conditions for which less toxic agents are available.
PY - 1977 SP - 247 EP - 51 T2 - The Medical journal of Australia TI - Agranulocytosis due to dapsone. VL - 2 SN - 0025-729X ER -