TY - JOUR KW - Antigens, Bacterial KW - Humans KW - Interferon-gamma KW - Interleukin-4 KW - Interleukin-5 KW - leprosy KW - Mycobacterium leprae KW - Th1 Cells AU - Dockrell H M AU - Young S K AU - Britton K AU - Brennan P J AU - Rivoire B AU - Waters M F AU - Lucas S B AU - Shahid F AU - Dojki M AU - Chiang T J AU - Ehsan Q AU - McAdam K P AU - Hussain R AB -

Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-gamma) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae antigens containing cell wall proteins or cytosolic and membrane proteins induced good IFN-gamma responses in tuberculoid leprosy patients. Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-gamma inducers.

BT - Infection and immunity C1 - http://www.ncbi.nlm.nih.gov/pubmed/8926118?dopt=Abstract DA - 1996 Oct IS - 10 J2 - Infect. Immun. LA - eng N2 -

Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-gamma) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae antigens containing cell wall proteins or cytosolic and membrane proteins induced good IFN-gamma responses in tuberculoid leprosy patients. Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-gamma inducers.

PY - 1996 SP - 4385 EP - 9 T2 - Infection and immunity TI - Induction of Th1 cytokine responses by mycobacterial antigens in leprosy. UR - https://iai.asm.org/content/iai/64/10/4385.full.pdf VL - 64 SN - 0019-9567 ER -