Various mechanisms for nerve damage in tuberculoid leprosy have been proposed. A common feature amongst them is the crucial role played by T-cells. Therefore, the present study was designed to determine the role of T-cells in the induction of nerve damage in leprosy using two different protocols for obtaining graded levels of T-cell depletion: (i) Cyclosporine A, for depletion of T-helper cells and (ii) Anti Thy 1.2, for total depletion of T-cells. The findings indicate that the early changes seen in the unmyelinated fibres may not involve T-cells. However, the later stages of nerve damage associated with demyelination are dependent on T-cell responses.
BT - Indian journal of leprosy C1 - http://www.ncbi.nlm.nih.gov/pubmed/8849913?dopt=Abstract CN - Infolep Library - available DA - 1995 Oct-Dec IS - 4 J2 - Indian J Lepr LA - eng N2 -Various mechanisms for nerve damage in tuberculoid leprosy have been proposed. A common feature amongst them is the crucial role played by T-cells. Therefore, the present study was designed to determine the role of T-cells in the induction of nerve damage in leprosy using two different protocols for obtaining graded levels of T-cell depletion: (i) Cyclosporine A, for depletion of T-helper cells and (ii) Anti Thy 1.2, for total depletion of T-cells. The findings indicate that the early changes seen in the unmyelinated fibres may not involve T-cells. However, the later stages of nerve damage associated with demyelination are dependent on T-cell responses.
PY - 1995 SP - 363 EP - 74 T2 - Indian journal of leprosy TI - Effect of T-cell depletion on bacterial multiplication and pattern of nerve damage in M. leprae-infected mice. VL - 67 SN - 0254-9395 ER -