TY - JOUR
KW - Adult
KW - Biopsy
KW - Female
KW - Humans
KW - Hypesthesia
KW - Lepromin
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Middle Aged
KW - Peripheral nerves
KW - Peripheral Nervous System Diseases
KW - Skin
AU - Mishra B
AU - Mukherjee A
AU - Girdhar A
AU - Husain S
AU - Malaviya G N
AU - Girdhar B K
AB - <p>Sixteen neuritic cases have been seen developing cutaneous lesions. These cutaneous lesions by and large appear within 4 months after the diagnosis of neuritic leprosy. Leprosy pathology in cutaneous lesions has been found ranging between indeterminate and borderline lepromatous group. Development of cutaneous lesions does not seem to be influenced by age, sex or number of nerves or lepromin status. Neither lesions seem to appear in any particular part of the body. Therapy, duration and type i.e. monodrug or multidrug, also does not seem to influence the development of cutaneous lesions in either way. It appears that neuritic cases with either very early (indeterminate) or with advanced multibacillary neural pathology may develop skin lesions. Skin lesion possibly appear following reversal reaction in skin. Cases with newly developed skin lesions well respond to standard therapy. Development of cutaneous lesions by neuritic cases possibly indicates towards the natural history of the disease, conforming to the hypothesis that leprosy is basically neural in inception and that all other forms emerge from it.</p>
BT - Acta leprologica
C1 - http://www.ncbi.nlm.nih.gov/pubmed/8711979?dopt=Abstract
DA - 1995
IS - 4
J2 - Acta Leprol
LA - eng
N2 - <p>Sixteen neuritic cases have been seen developing cutaneous lesions. These cutaneous lesions by and large appear within 4 months after the diagnosis of neuritic leprosy. Leprosy pathology in cutaneous lesions has been found ranging between indeterminate and borderline lepromatous group. Development of cutaneous lesions does not seem to be influenced by age, sex or number of nerves or lepromin status. Neither lesions seem to appear in any particular part of the body. Therapy, duration and type i.e. monodrug or multidrug, also does not seem to influence the development of cutaneous lesions in either way. It appears that neuritic cases with either very early (indeterminate) or with advanced multibacillary neural pathology may develop skin lesions. Skin lesion possibly appear following reversal reaction in skin. Cases with newly developed skin lesions well respond to standard therapy. Development of cutaneous lesions by neuritic cases possibly indicates towards the natural history of the disease, conforming to the hypothesis that leprosy is basically neural in inception and that all other forms emerge from it.</p>
PY - 1995
SP - 187
EP - 94
T2 - Acta leprologica
TI - Neuritic leprosy: further progression and significance.
VL - 9
SN - 0001-5938
ER -