TY - JOUR
KW - Adolescent
KW - Adult
KW - Autonomic Nervous System Diseases
KW - Child
KW - Cold Temperature
KW - Female
KW - Hand
KW - Humans
KW - Laser-Doppler Flowmetry
KW - leprosy
KW - Male
KW - Middle Aged
KW - Muscle, Skeletal
KW - Muscle, Smooth, Vascular
KW - Reflex
KW - Regional Blood Flow
KW - Skin
KW - Ultrasonography
AU - Wilder-Smith E P
AU - Wilder-Smith A J
AU - Nirkko A C
AB - <p>There are few tests to assess the function of small unmyelinated nerve fibers. One established test is the skin vasomotor reflex (SVMR), which uses laser doppler flow velocimetry. The SVMR has the disadvantages of being susceptible to interference (from change of temperature and alerting stimuli) and of requiring expensive equipment. An ultrasound doppler method, which is less expensive, can be used to detect muscle vasomotor reflex (MVMR) activity. We sought to compare the efficacy of these two methods in detecting dysfunction of small unmyelinated nerve fibers in patients with leprosy. SVMR was shown to be less sensitive (P < 0.01) and specific (P < 0.001) than MVMR. The favorable results of MVMR may be attributed to its lesser susceptibility to interfering sympathetic vasoconstriction from alerting stimuli. MVMR also reflects larger areas of blood vessel innervation than the laser doppler method. In leprosy, nerve damage is typically patchy and may be missed by the smaller sampling of the laser method.</p>
BT - Muscle & nerve
C1 - http://www.ncbi.nlm.nih.gov/pubmed/10883006?dopt=Abstract
DA - 2000 Jul
DO - 10.1002/1097-4598(200007)23:7<1105::aid-mus14>3.0.co;2-a
IS - 7
J2 - Muscle Nerve
LA - eng
N2 - <p>There are few tests to assess the function of small unmyelinated nerve fibers. One established test is the skin vasomotor reflex (SVMR), which uses laser doppler flow velocimetry. The SVMR has the disadvantages of being susceptible to interference (from change of temperature and alerting stimuli) and of requiring expensive equipment. An ultrasound doppler method, which is less expensive, can be used to detect muscle vasomotor reflex (MVMR) activity. We sought to compare the efficacy of these two methods in detecting dysfunction of small unmyelinated nerve fibers in patients with leprosy. SVMR was shown to be less sensitive (P < 0.01) and specific (P < 0.001) than MVMR. The favorable results of MVMR may be attributed to its lesser susceptibility to interfering sympathetic vasoconstriction from alerting stimuli. MVMR also reflects larger areas of blood vessel innervation than the laser doppler method. In leprosy, nerve damage is typically patchy and may be missed by the smaller sampling of the laser method.</p>
PY - 2000
SP - 1105
EP - 12
T2 - Muscle & nerve
TI - Skin and muscle vasomotor reflexes in detecting autonomic dysfunction in leprosy.
VL - 23
SN - 0148-639X
ER -