TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Anti-Infective Agents
KW - Child
KW - Drug Therapy, Combination
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Middle Aged
KW - Ofloxacin
KW - Prognosis
KW - Rifampin
AU - Sampoonachot P
AU - Bundit C
AU - Kuhacharoen N
AU - Peerapakorn S
AU - Kampirapap K
AU - Poomlek A
AU - Bampenyu S
AU - Tiasiri S
AU - Rungruang S
AU - Surasondhi S
AU - Supanwanit S
AU - Wiriyawipart S
AB - <p>The results of combined chemotherapy trials with regimens containing ofloxacin and rifampicin for the treatment of 60 multibacillary leprosy cases from January 1989 to September 1995 was reported. Clinical improvement was achieved by all regimens from the end of the first month. Most patients continued to improve for 3 years. Bacterial indices were gradually reduced during the treatment. Patients on regimens containing rifampicin were clear of M. leprae at the end of the 5th year. The complications and side-effects of ofloxacin and rifampicin were trivial and both drugs were well tolerated. Ofloxacin added to the current WHO recommended M.B.-MDT regimen may shorten the duration of treatment. Ofloxacin may be an alternative in suspected/proven rifampicin resistant cases or rifampicin contraindicated.</p>
BT - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
C1 - http://www.ncbi.nlm.nih.gov/pubmed/8708505?dopt=Abstract
DA - 1996 Apr
IS - 4
J2 - J Med Assoc Thai
LA - eng
N2 - <p>The results of combined chemotherapy trials with regimens containing ofloxacin and rifampicin for the treatment of 60 multibacillary leprosy cases from January 1989 to September 1995 was reported. Clinical improvement was achieved by all regimens from the end of the first month. Most patients continued to improve for 3 years. Bacterial indices were gradually reduced during the treatment. Patients on regimens containing rifampicin were clear of M. leprae at the end of the 5th year. The complications and side-effects of ofloxacin and rifampicin were trivial and both drugs were well tolerated. Ofloxacin added to the current WHO recommended M.B.-MDT regimen may shorten the duration of treatment. Ofloxacin may be an alternative in suspected/proven rifampicin resistant cases or rifampicin contraindicated.</p>
PY - 1996
SP - 210
EP - 7
T2 - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
TI - Combined chemotherapy trials with regimens containing ofloxacin and rifampicin for multibacillary leprosy patients.
VL - 79
SN - 0125-2208
ER -