Earlier we reported the presence of significant levels of antigalactocerebroside (GalC) antibodies in the sera of leprosy patients. This study corroborates the above result and also gives evidence for the presence of antibodies to the nonpolar ceramide (Cer) moiety of GalC. AntiCer antibody titres were higher as compared to antiGalC antibodies in all categories of leprosy. The specificity of antibodies directed to the Cer moiety was confirmed using Lactosyl-BSA and neutralization assays. Statistically significant and positive correlations were observed between antiGalC and antiCer antibodies. Responsiveness factors were computed using natural logarithmic transformation of the variables.
BT - Leprosy review C1 - http://www.ncbi.nlm.nih.gov/pubmed/8684259?dopt=Abstract CN - Infolep Library - available DA - 1996 Jun DO - 10.5935/0305-7518.19960010 IS - 2 J2 - Lepr Rev LA - eng N2 -Earlier we reported the presence of significant levels of antigalactocerebroside (GalC) antibodies in the sera of leprosy patients. This study corroborates the above result and also gives evidence for the presence of antibodies to the nonpolar ceramide (Cer) moiety of GalC. AntiCer antibody titres were higher as compared to antiGalC antibodies in all categories of leprosy. The specificity of antibodies directed to the Cer moiety was confirmed using Lactosyl-BSA and neutralization assays. Statistically significant and positive correlations were observed between antiGalC and antiCer antibodies. Responsiveness factors were computed using natural logarithmic transformation of the variables.
PY - 1996 SP - 95 EP - 103 T2 - Leprosy review TI - Antisphingolipid antibodies in the sera of leprosy patients. UR - http://leprev.ilsl.br/pdfs/1996/v67n2/pdf/v67n2a02.pdf VL - 67 SN - 0305-7518 ER -